About: Analysing DNA Microarray Data Using Boolean Techniques

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We address in this manuscript a problem arising in molecular biology, namely a problem of discovering dependencies among gene expression levels. The problem is formulated in mathematical terms as a search for a fully defined three valued function defined on three valued variables which is partially specified by the DNA microarray measurements. This formulation as well as our solution methods are strongly motivated by results in the area of logical analysis of data (LAD) and in the area of partially defined Boolean functions (pdBfs), in particular by procedures for finding fully defined extensions of pdBfs. On one hand we present several algorithms which (under some assumptions) construct the desired three valued functional extension of the input data, and on the other hand we derive several proofs showing that (under different assumptions) finding such an extension is NP-hard. We address in this manuscript a problem arising in molecular biology, namely a problem of discovering dependencies among gene expression levels. The problem is formulated in mathematical terms as a search for a fully defined three valued function defined on three valued variables which is partially specified by the DNA microarray measurements. This formulation as well as our solution methods are strongly motivated by results in the area of logical analysis of data (LAD) and in the area of partially defined Boolean functions (pdBfs), in particular by procedures for finding fully defined extensions of pdBfs. On one hand we present several algorithms which (under some assumptions) construct the desired three valued functional extension of the input data, and on the other hand we derive several proofs showing that (under different assumptions) finding such an extension is NP-hard. (en)
Title	Analysing DNA Microarray Data Using Boolean Techniques Analysing DNA Microarray Data Using Boolean Techniques (en)
skos:prefLabel	Analysing DNA Microarray Data Using Boolean Techniques Analysing DNA Microarray Data Using Boolean Techniques (en)
skos:notation	RIV/00216208:11320/11:10103932!RIV12-GA0-11320___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA201/07/0205), P(GAP202/10/1188), P(GD201/05/H014), P(GP201/07/P168), Z(MSM0021620838)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kučera, Petr Kronus, David Čepek, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Matematicko-fyzikální fakulta
http://linked.open...dnocenehoVysledku	185576
http://linked.open...ai/riv/idVysledku	RIV/00216208:11320/11:10103932
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Boolean Techniques; DNA Microarray (en)
http://linked.open.../riv/klicoveSlovo	Boolean Techniques DNA Microarray
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[E88A55D8269A]
http://linked.open...i/riv/nazevZdroje	Annals of Operations Research
http://linked.open...in/vavai/riv/obor	BA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Dynamic aspects of scheduling KnowSched: Knowledge Techniques in Scheduling Collegium Informaticum Boolean functions
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	188
http://linked.open...iv/tvurceVysledku	Kučera, Petr Kronus, David Čepek, Ondřej
http://linked.open...ain/vavai/riv/wos	000293183300005
http://linked.open...n/vavai/riv/zamer	Moderní metody, struktury a systémy informatiky
issn	0254-5330
number of pages	34 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10479-010-0723-0
http://localhost/t...ganizacniJednotka	11320

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