About: Structural and dynamic changes of the serum response element and the core domain of serum response factor induced by their association

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About: Structural and dynamic changes of the serum response element and the core domain of serum response factor induced by their association Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Transcriptional activity of serum response factor (SRF) is dependent on its binding to the CC(A/T)6GG box (CArG box) of serum response element (SRE). By Raman spectroscopy, we carried out a comparative analysis, in solution, of the complexes obtained from the association of core-SRF with 20-mer SREs bearing wild-type and mutated c-fos CArG boxes. In case of association with the wild type c-fos CArG box, the complex does not bring out the expected Raman signature of a stable bending of the targeted SRE but keeps a bend-linear conformer oligonucleotide interconversion. The linear conformer population is larger than that of free oligonucleotide. In the core-SRF moiety of the wild-type complex a large spectral change associated with the CO-groups from Asp and/or Glu residues shows that their ionization states and the strength of their interactions decrease as compared to those of mutated non-specific complexes. Transcriptional activity of serum response factor (SRF) is dependent on its binding to the CC(A/T)6GG box (CArG box) of serum response element (SRE). By Raman spectroscopy, we carried out a comparative analysis, in solution, of the complexes obtained from the association of core-SRF with 20-mer SREs bearing wild-type and mutated c-fos CArG boxes. In case of association with the wild type c-fos CArG box, the complex does not bring out the expected Raman signature of a stable bending of the targeted SRE but keeps a bend-linear conformer oligonucleotide interconversion. The linear conformer population is larger than that of free oligonucleotide. In the core-SRF moiety of the wild-type complex a large spectral change associated with the CO-groups from Asp and/or Glu residues shows that their ionization states and the strength of their interactions decrease as compared to those of mutated non-specific complexes. (en)
Title	Structural and dynamic changes of the serum response element and the core domain of serum response factor induced by their association Structural and dynamic changes of the serum response element and the core domain of serum response factor induced by their association (en)
skos:prefLabel	Structural and dynamic changes of the serum response element and the core domain of serum response factor induced by their association Structural and dynamic changes of the serum response element and the core domain of serum response factor induced by their association (en)
skos:notation	RIV/00216208:11320/10:10070495!RIV11-MSM-11320___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Štěpánek, Josef Kopecký, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Matematicko-fyzikální fakulta
http://linked.open...dnocenehoVysledku	290412
http://linked.open...ai/riv/idVysledku	RIV/00216208:11320/10:10070495
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Raman spectroscopy; specific recognition; c-fos; SRE; core-SRF (en)
http://linked.open.../riv/klicoveSlovo	Raman spectroscopy c-fos SRE core-SRF specific recognition
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BC0409E7E340]
http://linked.open...i/riv/nazevZdroje	Biochemical and Biophysical Research Communications
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	391
http://linked.open...iv/tvurceVysledku	Turpin, Pierre-Yves Štěpánek, Josef Kopecký, Vladimír Zentz, Christian Alpert, Bernard Mezzetti, Alberto Paulin, Denise
http://linked.open...ain/vavai/riv/wos	000273624500037
http://linked.open...n/vavai/riv/zamer	Fyzika molekulárních, makromolekulárních a biologických systémů
issn	0006-291X
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11320

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