About: Ion Channel Activity of Transmembrane Segment 6 of Escherichia coli Proton-Dependent Manganese Transporter     Goto   Sponge   NotDistinct   Permalink

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Description
  • Synthetic peptide corresponding to transmembrane segment TMS6 of secondary-active transporter MntH from Escherichia coli was used as a suitable alternative model enabling to study TMS structure, TMS interaction with membranes and also function of MntH. The secondary structure of the peptides was estimated in different environments using circular dichroism spectroscopy. These peptides interacted with and adopted helical conformation in lipid membranes. Electrophysiological experiments demonstrated that individual TMS were able under certain conditions to form ion channels in model biological membranes. Electrophysiological properties of these weakly cation-selective ion channels were strongly dependent on surrounding pH and the presence of manganese ion, as physiological substrate of MntH.
  • Synthetic peptide corresponding to transmembrane segment TMS6 of secondary-active transporter MntH from Escherichia coli was used as a suitable alternative model enabling to study TMS structure, TMS interaction with membranes and also function of MntH. The secondary structure of the peptides was estimated in different environments using circular dichroism spectroscopy. These peptides interacted with and adopted helical conformation in lipid membranes. Electrophysiological experiments demonstrated that individual TMS were able under certain conditions to form ion channels in model biological membranes. Electrophysiological properties of these weakly cation-selective ion channels were strongly dependent on surrounding pH and the presence of manganese ion, as physiological substrate of MntH. (en)
Title
  • Ion Channel Activity of Transmembrane Segment 6 of Escherichia coli Proton-Dependent Manganese Transporter
  • Ion Channel Activity of Transmembrane Segment 6 of Escherichia coli Proton-Dependent Manganese Transporter (en)
skos:prefLabel
  • Ion Channel Activity of Transmembrane Segment 6 of Escherichia coli Proton-Dependent Manganese Transporter
  • Ion Channel Activity of Transmembrane Segment 6 of Escherichia coli Proton-Dependent Manganese Transporter (en)
skos:notation
  • RIV/00216208:11320/10:10062292!RIV11-GA0-11320___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA204/07/0558), S, Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 264896
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11320/10:10062292
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CD spectroscopy; patch clamp; Nramp; MntH; membrane transport; divalent metal ions (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [8709C98F8B6E]
http://linked.open...i/riv/nazevZdroje
  • Biopolymers
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 93
http://linked.open...iv/tvurceVysledku
  • Chaloupka, Roman
  • Urbánková, Eva
  • Ňuňuková, Věra
  • Jelokhani-Niaraki, Masoud
http://linked.open...ain/vavai/riv/wos
  • 000279035900005
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-3525
number of pages
http://localhost/t...ganizacniJednotka
  • 11320
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