About: Omega-3 polyunsaturated fatty acids affect arrhythmogenic factors and attenuate susceptibility of the heart to malignant arrhythmias in an experimental model of human essential hypertension

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About: Omega-3 polyunsaturated fatty acids affect arrhythmogenic factors and attenuate susceptibility of the heart to malignant arrhythmias in an experimental model of human essential hypertension Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	HR v skorom aj pokročilom štádiu hypertenzie profitovali z konzumácie omega-3 PUFA najmä v dôsledku poklesu incidencie komorovej fibrilácie a lepšej schopnosti návratu do sínusového rytmu. Tieto antiarytmické účinky omega-3 PUFA sa dajú prinajmenšom čiastočne vysvetliť potlačením remodelácie gapjunctions,normalizáciou distribúcie Cx43, jeho proteínovej expresie, ako aj fosforylácie. Výsledky tejto štúdie podporujú profylaktické použitie omega-3 PUFA na zníženie kardiovaskulárneho rizika a incidencie malígnych arytmií u hypertenzných jedincov Omega-3 polyunsaturated fatty acids intake significantly reduced cardiovascular risk factors, suppressed incidence of ventricular fibrillation and facilitated sinus rhythm restoration in SHR at early and late stage of hypertension. The antiarrhythmic effects of omega-3 can be attributed to attenuation of abnormal myocardial Cx43 distribution, expression and phosphorylation as well as to positive modulation of PKC-epsilon and PKC-delta signaling and normalization of MyHC profiles. Findings support prophylactic use of omega-3 to minimize a risk for lethal arrhythmias in hypertensive individuals (en)
Title	Omega-3 polyunsaturated fatty acids affect arrhythmogenic factors and attenuate susceptibility of the heart to malignant arrhythmias in an experimental model of human essential hypertension (en) Omega-3 polynenasýtené mastné kyseliny ovplyvňujú arytmogénne faktory a znižujú náchylnosť srdca k malígnym arytmiám v experimentálnom modeli ľudskej esenciálnej hypertenzie
skos:prefLabel	Omega-3 polyunsaturated fatty acids affect arrhythmogenic factors and attenuate susceptibility of the heart to malignant arrhythmias in an experimental model of human essential hypertension (en) Omega-3 polynenasýtené mastné kyseliny ovplyvňujú arytmogénne faktory a znižujú náchylnosť srdca k malígnym arytmiám v experimentálnom modeli ľudskej esenciálnej hypertenzie
skos:notation	RIV/00216208:11310/14:10290395!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Žurmanová, Jitka Arnoštová, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	34196
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10290395
http://linked.open...riv/jazykVysledku	sla - slovenština
http://linked.open.../riv/klicovaSlova	myocardial connexin-43; ventricular fibrillation; omega-3 polyunsaturated fatty acids (en)
http://linked.open.../riv/klicoveSlovo	ventricular fibrillation myocardial connexin-43 omega-3 polyunsaturated fatty acids
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[11D8BA5A5357]
http://linked.open...i/riv/nazevZdroje	Cardiology Letters
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Soukup, Tomáš Slezák, Jan Žurmanová, Jitka Arnoštová, Petra Bačová, Barbara Knezl, Vladimír Radošinská, Jana Tribulová, Narcisa Beňová, Tamara Goncalvesová, Eva
issn	1338-3655
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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