About: Mechanosensors in integrin signaling: The emerging role of p130Cas

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings. Besides their role in the transmission of regulatory signals, these structures are also involved in mechanosensing and mechanotransduction. In the past few years, many research groups have been trying to elucidate the mechanisms and consequences of the mechanosensitivity of cells. In this review we discuss the role of the integrin pathway in cellular mechanosensing, focusing on primary mechanosensors, molecules that respond to mechanical stress by changing their conformation. We propose mechanisms by which p130Cas is involved in this process, and emphasize the importance of mechanosensing in cell physiology and the development of diseases. (C) 2014 The Authors. Published by Elsevier GmbH. Physicochemical interactions between the cell and its environment are crucial for morphogenesis, tissue homeostasis, remodeling and pathogenesis. Cells form specialized structures like focal adhesions and podosomes that are responsible for bi-directional information exchange between the cell and its surroundings. Besides their role in the transmission of regulatory signals, these structures are also involved in mechanosensing and mechanotransduction. In the past few years, many research groups have been trying to elucidate the mechanisms and consequences of the mechanosensitivity of cells. In this review we discuss the role of the integrin pathway in cellular mechanosensing, focusing on primary mechanosensors, molecules that respond to mechanical stress by changing their conformation. We propose mechanisms by which p130Cas is involved in this process, and emphasize the importance of mechanosensing in cell physiology and the development of diseases. (C) 2014 The Authors. Published by Elsevier GmbH. (en)
Title	Mechanosensors in integrin signaling: The emerging role of p130Cas Mechanosensors in integrin signaling: The emerging role of p130Cas (en)
skos:prefLabel	Mechanosensors in integrin signaling: The emerging role of p130Cas Mechanosensors in integrin signaling: The emerging role of p130Cas (en)
skos:notation	RIV/00216208:11310/14:10289123!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0061), P(GC13-24851J)
http://linked.open...iv/cisloPeriodika	10-12
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Brábek, Jan Rösel, Daniel Janoštiak, Radoslav Pataki, Andreea Csilla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	28161
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10289123
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p130Cas; Integrins; Podosomes; Focal adhesions; Mechanosensing (en)
http://linked.open.../riv/klicoveSlovo	Focal adhesions Mechanosensing Integrins Podosomes p130Cas
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[1F52C7310F6E]
http://linked.open...i/riv/nazevZdroje	European Journal of Cell Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Increasing of the R&D capacity at Charles University through new positions for graduates of doctoral studies Dissecting of BCAR1/CAS role in mechanosensing
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	93
http://linked.open...iv/tvurceVysledku	Brábek, Jan Janoštiak, Radoslav Rösel, Daniel Pataki, Andreea Csilla
http://linked.open...ain/vavai/riv/wos	000347271800009
issn	0171-9335
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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