About: Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1155/2014/463123
Description	The adenylyl cyclase (AC) signaling system plays a crucial role in the regulation of cardiac contractility. Here we analyzed the key components of myocardial AC signaling in the developing chick embryo and assessed the impact of selected beta-blocking agents on this system. Application of metoprolol and carvedilol, two commonly used beta-blockers, at embryonic day (ED) 8 significantly downregulated (by about 40%) expression levels of AC5, the dominant cardiac AC isoform, and the amount of Gs alpha protein at ED9. Activity of AC stimulated by forskolin was also significantly reduced under these conditions. Interestingly, when administered at ED4, these drugs did not produce such profound changes in the myocardial AC signaling system, except for markedly increased expression of Gi alpha protein. These data indicate that beta-blocking agents can strongly derange AC signaling during the first half of embryonic heart development. The adenylyl cyclase (AC) signaling system plays a crucial role in the regulation of cardiac contractility. Here we analyzed the key components of myocardial AC signaling in the developing chick embryo and assessed the impact of selected beta-blocking agents on this system. Application of metoprolol and carvedilol, two commonly used beta-blockers, at embryonic day (ED) 8 significantly downregulated (by about 40%) expression levels of AC5, the dominant cardiac AC isoform, and the amount of Gs alpha protein at ED9. Activity of AC stimulated by forskolin was also significantly reduced under these conditions. Interestingly, when administered at ED4, these drugs did not produce such profound changes in the myocardial AC signaling system, except for markedly increased expression of Gi alpha protein. These data indicate that beta-blocking agents can strongly derange AC signaling during the first half of embryonic heart development. (en)
Title	Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs (en)
skos:prefLabel	Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs (en)
skos:notation	RIV/00216208:11310/14:10272173!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP302/11/1308), S
http://linked.open...iv/cisloPeriodika	Jun
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hejnová, Lucie Novotný, Jiří Hahnová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	1634
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10272173
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	exposure; toxicity; physiology; malformations; risk; catecholamines; pregnancy; embryo; cardiovascular-disease; beta-adrenergic-receptor (en)
http://linked.open.../riv/klicoveSlovo	physiology embryo catecholamines pregnancy risk toxicity malformations exposure cardiovascular-disease beta-adrenergic-receptor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[570881B222F4]
http://linked.open...i/riv/nazevZdroje	BioMed Research International
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Epigenetic factors in myocardial morphogenesis
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	neuveden
http://linked.open...iv/tvurceVysledku	Novotný, Jiří Sedmera, David Hejnová, Lucie Kočková, Radka Hahnová, Klára Svatůňková, Jarmila
http://linked.open...ain/vavai/riv/wos	000338534700001
issn	2314-6133
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2014/463123
http://localhost/t...ganizacniJednotka	11310

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