About: First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds

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About: First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.dci.2014.02.010
Description	Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Ayes: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds. Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Ayes: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds. (en)
Title	First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds (en)
skos:prefLabel	First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds (en)
skos:notation	RIV/00216208:11310/14:10218698!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP505/10/1871), S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Albrecht, Tomáš Vinkler, Michal Bainová, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	16929
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/14:10218698
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Flagellin; Pseudogene; Toll-like receptor 5; Innate immunity; Expression; Birds (en)
http://linked.open.../riv/klicoveSlovo	Expression Innate immunity Birds Flagellin Pseudogene Toll-like receptor 5
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[840E17F85A29]
http://linked.open...i/riv/nazevZdroje	Developmental and Comparative Immunology
http://linked.open...in/vavai/riv/obor	EG
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Toll-like receptors in passerine birds: description, characterization of polymorphism and evolutionary consequences of allelic variation
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Albrecht, Tomáš Bryja, Josef Vinkler, Michal Bryjova, Anna Kralova, Tereza Bainová, Hana
http://linked.open...ain/vavai/riv/wos	000335624800016
issn	0145-305X
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.dci.2014.02.010
http://localhost/t...ganizacniJednotka	11310

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