About: First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds     Goto   Sponge   NotDistinct   Permalink

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Description
  • Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Ayes: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds.
  • Toll-like receptor 5 (TLR5) is a Pattern-recognition receptor responsible for microbial flagellin detection in vertebrates and, hence, recognition of potentially pathogenic bacteria. Herein, we report emergence of TLR5 pseudogene in several phylogenetic lineages of passerine birds (Ayes: Passeriformes). Out of 47 species examined in this study 18 possessed a TLR5 pseudogene. Phylogenetic analysis together with the type of mutation responsible for pseudogenization indicate that TLR5 pseudogene emerged at least seven times independently in passerines. Lack of any functional copy of the gene has been verified based on TLR5 mRNA blood expression in four species representing the four main passerine lineages possessing the TLR5 pseudogene. Our results suggest that the non-functional TLR5 variant is fixed in those lineages or, at least, that individuals homozygote in the TLR5 pseudogene are frequent in the investigated species. Further research is needed to assess the impact of the TLR5 loss on immunological performance in birds. (en)
Title
  • First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds
  • First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds (en)
skos:prefLabel
  • First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds
  • First evidence of independent pseudogenization of Toll-like receptor 5 in passerine birds (en)
skos:notation
  • RIV/00216208:11310/14:10218698!RIV15-MSM-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GAP505/10/1871), S
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 16929
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/14:10218698
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Flagellin; Pseudogene; Toll-like receptor 5; Innate immunity; Expression; Birds (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [840E17F85A29]
http://linked.open...i/riv/nazevZdroje
  • Developmental and Comparative Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 45
http://linked.open...iv/tvurceVysledku
  • Albrecht, Tomáš
  • Bryja, Josef
  • Vinkler, Michal
  • Bryjova, Anna
  • Kralova, Tereza
  • Bainová, Hana
http://linked.open...ain/vavai/riv/wos
  • 000335624800016
issn
  • 0145-305X
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.dci.2014.02.010
http://localhost/t...ganizacniJednotka
  • 11310
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