About: Single blastomere expression profiling of Xenopus laevis embryos of 8 to 32-cells reveals developmental asymmetry

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About: Single blastomere expression profiling of Xenopus laevis embryos of 8 to 32-cells reveals developmental asymmetry Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1038/srep02278
Description	We have measured the expression of 41 maternal mRNAs in individual blastomeres collected from the 8 to 32-cell Xenopus laevis embryos to determine when and how asymmetry in the body plan is introduced. We demonstrate that the asymmetry along the animal-vegetal axis in the oocyte is transferred to the daughter cells during early cell divisions. All studied mRNAs are distributed evenly among the set of animal as well as vegetal blastomeres. We find no asymmetry in mRNA levels that might be ascribed to the dorso-ventral specification or the left-right axis formation. We hypothesize that while the animal-vegetal asymmetry is a consequence of mRNA gradients, the dorso-ventral and left-right axes specifications are induced by asymmetric distribution of other biomolecules, probably proteins. We have measured the expression of 41 maternal mRNAs in individual blastomeres collected from the 8 to 32-cell Xenopus laevis embryos to determine when and how asymmetry in the body plan is introduced. We demonstrate that the asymmetry along the animal-vegetal axis in the oocyte is transferred to the daughter cells during early cell divisions. All studied mRNAs are distributed evenly among the set of animal as well as vegetal blastomeres. We find no asymmetry in mRNA levels that might be ascribed to the dorso-ventral specification or the left-right axis formation. We hypothesize that while the animal-vegetal asymmetry is a consequence of mRNA gradients, the dorso-ventral and left-right axes specifications are induced by asymmetric distribution of other biomolecules, probably proteins. (en)
Title	Single blastomere expression profiling of Xenopus laevis embryos of 8 to 32-cells reveals developmental asymmetry Single blastomere expression profiling of Xenopus laevis embryos of 8 to 32-cells reveals developmental asymmetry (en)
skos:prefLabel	Single blastomere expression profiling of Xenopus laevis embryos of 8 to 32-cells reveals developmental asymmetry Single blastomere expression profiling of Xenopus laevis embryos of 8 to 32-cells reveals developmental asymmetry (en)
skos:notation	RIV/00216208:11310/13:10191728!RIV14-MSM-11310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA301/09/1752), S, Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	July
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Šídová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	105322
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/13:10191728
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	localization; specification; oocyte; drosophila; determinants; messenger-rna; vegetal cortex; prospective areas; cortical rotation; dorsal-ventral axis (en)
http://linked.open.../riv/klicoveSlovo	drosophila cortical rotation dorsal-ventral axis vegetal cortex determinants specification messenger-rna prospective areas localization oocyte
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2996E03ED99F]
http://linked.open...i/riv/nazevZdroje	Scientific Reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Formation of spatiotemporal molecular gradients in early development of Xenopus laevis
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Kubista, Mikael Flachsová, Monika Šindelka, Radek
http://linked.open...ain/vavai/riv/wos	000322153800006
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	2045-2322
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/srep02278
http://localhost/t...ganizacniJednotka	11310

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