About: Bis(phosphonate)-Building Blocks Modified with Fluorescent Dyes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1002/hc.21108
Description	Preparation of two benzylic bis(phosphonic acids) modified with primary amine or carboxylic acid groups on the benzene ring is described. These compounds were prepared and characterized in the form of both bis(phosphonate) tetraesters and corresponding free acids. The phosphonic acid esters are suitable for further derivation, mainly for conjugation through the amide bond. Mild conversion of the bis(phosphonate) esters to free acids using trimethylsilylbromide allowed to work with functional groups sensitive to conditions of acidic and/or alkaline hydrolysis. Three bis(phosphonate)-containing fluorescent probes were prepared from the building blocks, utilizing amide and sulfamide bonds as spacers. Dyes containing the dansyl group, rhodamine B, and fluorescein were chosen due to their common availability and low cost. The prepared bis(phosphonate)-building blocks and modified fluorescent probes were used for adsorption studies with hydroxyapatite, the commonly used model of bone tissue. Sorption ability of the prepared bis(phosphonate) compounds was similar to that of pamidronate. Preparation of two benzylic bis(phosphonic acids) modified with primary amine or carboxylic acid groups on the benzene ring is described. These compounds were prepared and characterized in the form of both bis(phosphonate) tetraesters and corresponding free acids. The phosphonic acid esters are suitable for further derivation, mainly for conjugation through the amide bond. Mild conversion of the bis(phosphonate) esters to free acids using trimethylsilylbromide allowed to work with functional groups sensitive to conditions of acidic and/or alkaline hydrolysis. Three bis(phosphonate)-containing fluorescent probes were prepared from the building blocks, utilizing amide and sulfamide bonds as spacers. Dyes containing the dansyl group, rhodamine B, and fluorescein were chosen due to their common availability and low cost. The prepared bis(phosphonate)-building blocks and modified fluorescent probes were used for adsorption studies with hydroxyapatite, the commonly used model of bone tissue. Sorption ability of the prepared bis(phosphonate) compounds was similar to that of pamidronate. (en)
Title	Bis(phosphonate)-Building Blocks Modified with Fluorescent Dyes Bis(phosphonate)-Building Blocks Modified with Fluorescent Dyes (en)
skos:prefLabel	Bis(phosphonate)-Building Blocks Modified with Fluorescent Dyes Bis(phosphonate)-Building Blocks Modified with Fluorescent Dyes (en)
skos:notation	RIV/00216208:11310/13:10140213!RIV14-GA0-11310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GAP207/11/1437), P(LD13012), S, Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	David, Tomáš Kotek, Jan Lukeš, Ivan Hermann, Petr Kubíček, Vojtěch Tošner, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	63600
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/13:10140213
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hydroxyapatite; agents; affinity; pet; bisphosphonates; cancer role; dilute-solutions; imaging bone metastases; iron-oxide nanoparticles; peptide coupling reagents (en)
http://linked.open.../riv/klicoveSlovo	cancer role dilute-solutions imaging bone metastases peptide coupling reagents affinity hydroxyapatite pet agents iron-oxide nanoparticles bisphosphonates
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9B7003ECF4EF]
http://linked.open...i/riv/nazevZdroje	Heteroatom Chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Ligands for complexation of lanthanides Novel classes of contrast agents for magnetic resonance imaging
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	David, Tomáš Hermann, Petr Kotek, Jan Kubíček, Vojtěch Lukeš, Ivan Tošner, Zdeněk
http://linked.open...ain/vavai/riv/wos	000323888400009
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1042-7163
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/hc.21108
http://localhost/t...ganizacniJednotka	11310

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