About: Rapid Supercritical Fluid Chromatography Method for Separation of Chlorthalidone Enantiomers

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Supercritical fluid chromatography employing chiral stationary phases is a popular separation technique to perform enantioselective separations. The main advantages of supercritical fluid chromatography are low analysis time, low consumption of organic modifiers, and therefore lower costs and higher environmental friendliness. A novel method for the separation of chlorthalidone enantiomers, widely used diuretic drug, is reported that clearly demonstrates the advantages of supercritical fluid chromatography. The effects of the amount and type of organic modifiers, temperature, and back pressure on enantioselectivity and resolution of the enantiomers were evaluated. The baseline separation was achieved in less than 2.5 min in the optimized system composed of Chiralpak AD column, mobile phase CO2/ MeOH 50/50 (v/v), temperature 40C, a flow rate of 4.0mL/min, and 120 bar back pressure. Moreover, enantiomers of chlorthalidone were determined in two commercially available pharmaceuticals. The proposed method may be easily transferred to a semi-preparative scale. Supercritical fluid chromatography employing chiral stationary phases is a popular separation technique to perform enantioselective separations. The main advantages of supercritical fluid chromatography are low analysis time, low consumption of organic modifiers, and therefore lower costs and higher environmental friendliness. A novel method for the separation of chlorthalidone enantiomers, widely used diuretic drug, is reported that clearly demonstrates the advantages of supercritical fluid chromatography. The effects of the amount and type of organic modifiers, temperature, and back pressure on enantioselectivity and resolution of the enantiomers were evaluated. The baseline separation was achieved in less than 2.5 min in the optimized system composed of Chiralpak AD column, mobile phase CO2/ MeOH 50/50 (v/v), temperature 40C, a flow rate of 4.0mL/min, and 120 bar back pressure. Moreover, enantiomers of chlorthalidone were determined in two commercially available pharmaceuticals. The proposed method may be easily transferred to a semi-preparative scale. (en)
Title	Rapid Supercritical Fluid Chromatography Method for Separation of Chlorthalidone Enantiomers Rapid Supercritical Fluid Chromatography Method for Separation of Chlorthalidone Enantiomers (en)
skos:prefLabel	Rapid Supercritical Fluid Chromatography Method for Separation of Chlorthalidone Enantiomers Rapid Supercritical Fluid Chromatography Method for Separation of Chlorthalidone Enantiomers (en)
skos:notation	RIV/00216208:11310/13:10139879!RIV14-MSM-11310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(LH11018), S, Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vozka, Jiří Tesařová, Eva Kalíková, Květa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	101491
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/13:10139879
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SFC; Saccharide based chiral stationary phase; Chlorthalidone; Chiral separation (en)
http://linked.open.../riv/klicoveSlovo	SFC Chlorthalidone Saccharide based chiral stationary phase Chiral separation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[93B326DDB77D]
http://linked.open...i/riv/nazevZdroje	Analytical Letters
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Cyclofructans and their derivatives as new chiral selectors for liquid chromatography and capillary electrophoresis
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Kalíková, Květa Tesařová, Eva Vozka, Jiří
http://linked.open...ain/vavai/riv/wos	000327180300006
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0003-2719
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1080/00032719.2013.814058
http://localhost/t...ganizacniJednotka	11310

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