About: Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice

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About: Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.reprotox.2012.05.095
Description	Tetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA. Tetrabromobisphenol A (TBBPA) is a substance widely used in industry as a flame retardant. TBBPA was found in the environment and was detected even in the human body. The effect of this chemical was observed in different cell lines in vitro and it is supposed that TBBPA may affect various hormonal systems in vivo. In this study we examined the effect of TBBPA on the reproductive parameters of two generations of outbred mice in vivo. Experimental and control animals of F1 generation were bred in various conditions to enable evaluation of the possible trans-generational effect. An increased incidence of apoptosis in the testes and changes in the morphometry of seminiferous tubules was detected in the experimental animals. In addition, changes in the expression pattern of selected genes encoding proteins that play an important role during spermatogenesis were observed. In contrast, sperm quality and reproduction were not affected by TBBPA. (en)
Title	Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice (en)
skos:prefLabel	Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice Effect of tetrabrombisphenol A on induction of apoptosis in the testes and changes in expression of selected testicular genes in CD1 mice (en)
skos:notation	RIV/00216208:11310/13:10138901!RIV14-MSM-11310___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M06011), P(2B06151), P(GA523/09/1793), P(GD523/08/H064), P(NS10009), Z(AV0Z50520701)
http://linked.open...iv/cisloPeriodika	January
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Dostálová, Pavla Žatecká, Eva Děd, Lukáš Dorosh, Andriy
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	71779
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/13:10138901
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Gene expression; Apoptosis; Histopathology of testes; Spermatogenesis; Reproductive parameters; Fertility; Tetrabromobisphenol A (en)
http://linked.open.../riv/klicoveSlovo	Histopathology of testes Reproductive parameters Tetrabromobisphenol A Apoptosis Gene expression Spermatogenesis Fertility
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9C63E8D4A763]
http://linked.open...i/riv/nazevZdroje	Reproductive Toxicology
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Biodegradation of polybrominated compounds, monitoring of concentration changes of pollutants and their intermediates in the environment Effect of endocrine disruptors on reproductive parameters and expression of selected genes in mouse gonads. Expression of genes and proteins playing a role in the human reproduction - damage biomarkers The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment. Biotechnologies of mammalian gametes
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Elzeinová, Fatima Pěknicová, Jana Žatecká, Eva Dorosh, Andriy Děd, Lukáš Margaryan, Hasmik Dostálová, Pavla Kubatová, Alena
http://linked.open...ain/vavai/riv/wos	000314003900005
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR
issn	0890-6238
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.reprotox.2012.05.095
http://localhost/t...ganizacniJednotka	11310

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