About: HPLC Method for Chiral Separation and Quantification of Antidepressant Citalopram and Its Precursor Citadiol

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1007/s10337-013-2426-6
Description	HPLC method enabling chiral separation and determination of citalopram (CIT), a widely used antidepressant, and its synthetic precursor citadiol in one analysis was developed and validated. Moreover, supercritical fluid chromatography was also tested and was proved to be less effective for this separation purpose. The optimized HPLC system was composed of Chiralcel OD-H column and n-hexane/propane-2-ol/triethylamine 96/4/0.1 (v/v/v) as mobile phase, column temperature 25 C, flow rate 1.0 mL min-1, UV detection at 250 nm. The effects of amount of propane-2-ol, triethylamine addition, and temperature on enantioselectivity and resolution of the enantiomers were evaluated. The method was found to be suitable for determination of the enantiomeric purity of CIT in bulk drugs. Enantiomers of CIT were determined in two commercially available pharmaceuticals. HPLC method enabling chiral separation and determination of citalopram (CIT), a widely used antidepressant, and its synthetic precursor citadiol in one analysis was developed and validated. Moreover, supercritical fluid chromatography was also tested and was proved to be less effective for this separation purpose. The optimized HPLC system was composed of Chiralcel OD-H column and n-hexane/propane-2-ol/triethylamine 96/4/0.1 (v/v/v) as mobile phase, column temperature 25 C, flow rate 1.0 mL min-1, UV detection at 250 nm. The effects of amount of propane-2-ol, triethylamine addition, and temperature on enantioselectivity and resolution of the enantiomers were evaluated. The method was found to be suitable for determination of the enantiomeric purity of CIT in bulk drugs. Enantiomers of CIT were determined in two commercially available pharmaceuticals. (en)
Title	HPLC Method for Chiral Separation and Quantification of Antidepressant Citalopram and Its Precursor Citadiol HPLC Method for Chiral Separation and Quantification of Antidepressant Citalopram and Its Precursor Citadiol (en)
skos:prefLabel	HPLC Method for Chiral Separation and Quantification of Antidepressant Citalopram and Its Precursor Citadiol HPLC Method for Chiral Separation and Quantification of Antidepressant Citalopram and Its Precursor Citadiol (en)
skos:notation	RIV/00216208:11310/13:10134203!RIV14-MSM-11310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(LH11018), S, Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	9-10
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Geryk, Radim Vozka, Jiří Tesařová, Eva Kalíková, Květa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	78190
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/13:10134203
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chiralcel OD-H column; Citadiol; Citalopram; Chiral separations; SFC; HPLC (en)
http://linked.open.../riv/klicoveSlovo	Chiral separations Chiralcel OD-H column Citadiol Citalopram SFC HPLC
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[C32AD2D7AD61]
http://linked.open...i/riv/nazevZdroje	Chromatographia
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Cyclofructans and their derivatives as new chiral selectors for liquid chromatography and capillary electrophoresis
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Kalíková, Květa Tesařová, Eva Vozka, Jiří Geryk, Radim
http://linked.open...ain/vavai/riv/wos	000318168100006
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0009-5893
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10337-013-2426-6
http://localhost/t...ganizacniJednotka	11310

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