About: Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ivb.cz/folia/contents/Content_obsah.htm
Description	In humans, CD46 has been detected on the acrosomal membrane in sperm, in contrast to widespread surface expression on somatic cells where it plays a key role in the protection from complement attack. In rodents, CD46 is expressed solely on the acrosomal membrane of mature sperm and their immediate precursors, spermatids. A monoclonal antibody against the short consensus repeat (SCR1) ectodomain of CD46 blocks binding of human sperm to zona-free oocytes in vitro. However, CD46-knockout mice are fertile and have an accelerated spontaneous acrosome reaction. Wild-caught field mice (Apodemus) also exhibit a rapid acrosome reaction and CD46 is not expressed in Apodemus sperm. CD46 may, therefore, play a role in stabilization of the acrosomal membrane. Two other complement regulatory proteins, CD55 and CD59, are localized on the plasma membrane of mammalian sperm. In human sperm, CD55 and CD59 are expressed also on the inner acrosomal membrane. It remains to be clarified what is the role of CD46, CD55 and CD59 during fertilization and what are the advantages of not expressing CD46 in field mice sperm. In humans, CD46 has been detected on the acrosomal membrane in sperm, in contrast to widespread surface expression on somatic cells where it plays a key role in the protection from complement attack. In rodents, CD46 is expressed solely on the acrosomal membrane of mature sperm and their immediate precursors, spermatids. A monoclonal antibody against the short consensus repeat (SCR1) ectodomain of CD46 blocks binding of human sperm to zona-free oocytes in vitro. However, CD46-knockout mice are fertile and have an accelerated spontaneous acrosome reaction. Wild-caught field mice (Apodemus) also exhibit a rapid acrosome reaction and CD46 is not expressed in Apodemus sperm. CD46 may, therefore, play a role in stabilization of the acrosomal membrane. Two other complement regulatory proteins, CD55 and CD59, are localized on the plasma membrane of mammalian sperm. In human sperm, CD55 and CD59 are expressed also on the inner acrosomal membrane. It remains to be clarified what is the role of CD46, CD55 and CD59 during fertilization and what are the advantages of not expressing CD46 in field mice sperm. (en)
Title	Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction (en)
skos:prefLabel	Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction (en)
skos:notation	RIV/00216208:11310/12:10125313!RIV13-MSM-11310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(1M06011), S, Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Stopka, Pavel Frolíková, Michaela Dvořáková-Hortová, Kateřina Stopková, Romana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	165983
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/12:10125313
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	human; rodent; sperm; CD59; CD55; CD46 (en)
http://linked.open.../riv/klicoveSlovo	human sperm rodent CD46 CD55 CD59
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8C563097F815]
http://linked.open...i/riv/nazevZdroje	Folia Zoologica
http://linked.open...in/vavai/riv/obor	EG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Frolíková, Michaela Stopka, Pavel Dvořáková-Hortová, Kateřina Stopková, Romana Antalikova, Jana Johnson, Peter M.
http://linked.open...ain/vavai/riv/wos	000304292800011
http://linked.open...n/vavai/riv/zamer	Ekologické procesy v evoluci modelových skupin organismů
issn	0139-7893
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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