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  • It is well known that antagonists of N-type voltage-gated calcium channels inhibit the evoked quantal release of acetylcholine in amphibian neuromuscular synapses. This, however, does not exclude the functional expression of other types of voltage-gated calcium channels in these nerve terminals. Using immunocytochemistry, we detected the expression of the alpha1A subunit of P/Q-type calcium channels (that is otherwise typical of mammalian motor nerve endings) in the frog neuromuscular junction. In addition, we demonstrated that the P/Q-type channel blocker omega-agatoxin IVA (20 nM) reduced the action potential-induced calcium transient and significantly decreased both spontaneous and evoked mediator release. Our data indicates the functional expression of P/Q-type calcium channels in the frog motor nerve ending which participate in acetylcholine release.
  • It is well known that antagonists of N-type voltage-gated calcium channels inhibit the evoked quantal release of acetylcholine in amphibian neuromuscular synapses. This, however, does not exclude the functional expression of other types of voltage-gated calcium channels in these nerve terminals. Using immunocytochemistry, we detected the expression of the alpha1A subunit of P/Q-type calcium channels (that is otherwise typical of mammalian motor nerve endings) in the frog neuromuscular junction. In addition, we demonstrated that the P/Q-type channel blocker omega-agatoxin IVA (20 nM) reduced the action potential-induced calcium transient and significantly decreased both spontaneous and evoked mediator release. Our data indicates the functional expression of P/Q-type calcium channels in the frog motor nerve ending which participate in acetylcholine release. (en)
Title
  • Voltage-dependent P/Q-type calcium channels at the frog neuromuscular junction
  • Voltage-dependent P/Q-type calcium channels at the frog neuromuscular junction (en)
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  • Voltage-dependent P/Q-type calcium channels at the frog neuromuscular junction
  • Voltage-dependent P/Q-type calcium channels at the frog neuromuscular junction (en)
skos:notation
  • RIV/00216208:11310/11:10106766!RIV12-MSM-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 239496
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/11:10106766
http://linked.open...riv/jazykVysledku
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  • N- and P/Q-type calcium channels; Acetylcholine release; Motor nerve terminal; Neuromuscular transmission (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [CE7D8D617525]
http://linked.open...i/riv/nazevZdroje
  • Physiological Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 60
http://linked.open...iv/tvurceVysledku
  • Vyskočil, František
  • Malomouzh, A. I.
  • Nikolsky, E. E.
  • Nurullin, L. F.
  • Bukharaeva, E. A.
  • Mukhitov, A. R.
  • Petrova, N. V.
  • Samigullin, D. V.
  • Tsentsevytsky, A. N.
http://linked.open...ain/vavai/riv/wos
  • 000298159900010
issn
  • 0862-8408
number of pages
http://localhost/t...ganizacniJednotka
  • 11310
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