About: Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.tet.2011.08.079
Description	The synthesis of piperidines and piperidines derivatives in enantiopure fashion have been a challenging goal for organic chemists. In this report we developed a nice cascade reaction for piperidine derivatives based in an amidomalonate Michael addition to enals followed by an intramolecular hemiaminal formation with good yields and enantioselectivities. Moreover we studied the %22in situ%22 intramolecular cyclization of this hemiaminals with alcohols forming fused piperidine-oxazolidines. The synthesis of piperidines and piperidines derivatives in enantiopure fashion have been a challenging goal for organic chemists. In this report we developed a nice cascade reaction for piperidine derivatives based in an amidomalonate Michael addition to enals followed by an intramolecular hemiaminal formation with good yields and enantioselectivities. Moreover we studied the %22in situ%22 intramolecular cyclization of this hemiaminals with alcohols forming fused piperidine-oxazolidines. (en)
Title	Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines (en)
skos:prefLabel	Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines Highly enantioselective organocatalytic cascade reaction for the synthesis of piperidines and oxazolidines (en)
skos:notation	RIV/00216208:11310/11:10105194!RIV12-GA0-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP203/09/P193), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	46
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Veselý, Jan Číhalová, Sylva Dračínský, Martin Humpl, Marek Schimer, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	202073
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/11:10105194
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	derivatives; (-)-paroxetine; acid; atom economy; formal synthesis; azomethine ylides; 1,3-dipolar cycloaddition; one-pot; alpha,beta-unsaturated aldehydes; Diels-Alder reaction (en)
http://linked.open.../riv/klicoveSlovo	3-dipolar cycloaddition alpha azomethine ylides beta-unsaturated aldehydes 1 Diels-Alder reaction acid derivatives (-)-paroxetine atom economy formal synthesis one-pot
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8366423F3036]
http://linked.open...i/riv/nazevZdroje	Tetrahedron
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Enantioselective synthesis of N- and S-containing heterocycles via organocatalysis: The way for preparation of biologically active compounds.
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	67
http://linked.open...iv/tvurceVysledku	Dračínský, Martin Veselý, Jan Číhalová, Sylva Rios, Ramon Humpl, Marek Moyano, Albert Schimer, Jiří Valero, Guillem
http://linked.open...ain/vavai/riv/wos	000296546700014
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0040-4020
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.tet.2011.08.079
http://localhost/t...ganizacniJednotka	11310

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