About: Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.5562/cca1738
Description	The goal of the present study was to separate a set of benzodiazepines, namely bromazepam, oxazepam, nitrazepam, chlordiazepoxide, flunitrazepam, lormetazepam and diazepam by analytical scale HPLC and CZE. The both methods for separation of these seven compounds from the 1,4-benzodiazepine group were optimized and compared. LODs and LOQs were determined under the optimized conditions in the both methods. The corresponding LOD and LOQ values are approximately three orders of magnitude lower in HPLC than in CZE. As expected, elution order was found to be different for the both techniques. As a result of a critical collation of all the parameters considered, RP-HPLC was found to be more suitable for determination of the set of benzodiazepines. A real sample analysis was performed under optimized conditions to demonstrate applicability of the proposed analytical methods. The goal of the present study was to separate a set of benzodiazepines, namely bromazepam, oxazepam, nitrazepam, chlordiazepoxide, flunitrazepam, lormetazepam and diazepam by analytical scale HPLC and CZE. The both methods for separation of these seven compounds from the 1,4-benzodiazepine group were optimized and compared. LODs and LOQs were determined under the optimized conditions in the both methods. The corresponding LOD and LOQ values are approximately three orders of magnitude lower in HPLC than in CZE. As expected, elution order was found to be different for the both techniques. As a result of a critical collation of all the parameters considered, RP-HPLC was found to be more suitable for determination of the set of benzodiazepines. A real sample analysis was performed under optimized conditions to demonstrate applicability of the proposed analytical methods. (en)
Title	Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE (en)
skos:prefLabel	Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE (en)
skos:notation	RIV/00216208:11310/11:10102982!RIV12-GA0-11310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA203/08/1428), S, Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Tesařová, Eva Kalíková, Květa Riesová, Martina Chudoba, Richard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	228905
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/11:10102982
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pharmaceuticals; benzodiazepines; CZE; RP-HPLC (en)
http://linked.open.../riv/klicoveSlovo	CZE benzodiazepines pharmaceuticals RP-HPLC
http://linked.open...odStatuVydavatele	HR - Chorvatská republika
http://linked.open...ontrolniKodProRIV	[16B8F8C7CBB2]
http://linked.open...i/riv/nazevZdroje	Croatica Chemica Acta
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Capillary electrophoresis with multidimensinal detection and its application to separation and characterization of biopolymers
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	84
http://linked.open...iv/tvurceVysledku	Kalíková, Květa Tesařová, Eva Riesová, Martina Chudoba, Richard Schmid, Martin G.
http://linked.open...ain/vavai/riv/wos	000298934200006
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0011-1643
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.5562/cca1738
http://localhost/t...ganizacniJednotka	11310

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