About: Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis

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About: Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.molbiopara.2010.10.004
Description	The arginine dihydrolase (ADH) pathway has an analogous function to the urea cycle in mitochondria-containing cells, by removing nitrogen from amino acids and generating ATP. Subcellular localization of the ADH pathway enzymes in Trichomonas vagina lis revealed that arginine deiminase (ADI) localizes to the hydrogenosome, a mitochondrion-like organelle of anaerobic protists. However the other enzymes of the ADH pathway, ornithine carbamyltransferase and carbamate kinase localize to the cytosol. Three gene sequences of T. vaginalis ADI (ADI 1-3) were identified in the T. vaginalis genome, all having putative mitochondrial targeting sequences. The ADI sequences were cloned and used to probe T. vaginalis using a carboxyterminal di-hemogglutinin epitope tag which demonstrated co-localization with malic enzyme confirming the hydrogenosome localization of this enzyme. The arginine dihydrolase (ADH) pathway has an analogous function to the urea cycle in mitochondria-containing cells, by removing nitrogen from amino acids and generating ATP. Subcellular localization of the ADH pathway enzymes in Trichomonas vagina lis revealed that arginine deiminase (ADI) localizes to the hydrogenosome, a mitochondrion-like organelle of anaerobic protists. However the other enzymes of the ADH pathway, ornithine carbamyltransferase and carbamate kinase localize to the cytosol. Three gene sequences of T. vaginalis ADI (ADI 1-3) were identified in the T. vaginalis genome, all having putative mitochondrial targeting sequences. The ADI sequences were cloned and used to probe T. vaginalis using a carboxyterminal di-hemogglutinin epitope tag which demonstrated co-localization with malic enzyme confirming the hydrogenosome localization of this enzyme. (en)
Title	Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis (en)
skos:prefLabel	Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis (en)
skos:notation	RIV/00216208:11310/11:10099222!RIV12-MSM-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC07032), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hampl, Vladimír Tachezy, Jan Šmíd, Ondřej Šuťák, Róbert
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	203126
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/11:10099222
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Arginine deiminase; Arginine dihydrolase pathway; Mitochondrion-like organelle; Hydrogenosome; Trichomonas vaginalis (en)
http://linked.open.../riv/klicoveSlovo	Trichomonas vaginalis Arginine deiminase Arginine dihydrolase pathway Hydrogenosome Mitochondrion-like organelle
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[4E881F853278]
http://linked.open...i/riv/nazevZdroje	Molecular and Biochemical Parasitology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Functional Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	176
http://linked.open...iv/tvurceVysledku	Hampl, Vladimír Tachezy, Jan Brian, Lam Diessi, Daniele Fiori, Pier L. Morada, Mary Rappelli, Paola Yarlett, Nigel Šmíd, Ondřej Šuťák, Róbert
http://linked.open...ain/vavai/riv/wos	000287284800007
http://linked.open...n/vavai/riv/zamer	Signaling and cellular response mechanisms
issn	0166-6851
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molbiopara.2010.10.004
http://localhost/t...ganizacniJednotka	11310

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