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| Description
| - Tc-99m-phosphonate structures are well established tracers for bone tumour imaging. Our objective was to investigate different Ga-68-labelled phosphonate ligands concerning labelling kinetics, binding to hydroxyapatite and bone imaging using mu-PET. Seven macrocyclic phosphorus-containing ligands and EDTMP were labelled in nanomolar scale with n.c.a. Ga-68 in Na-HEPES buffer at pH similar to 4. Except for DOTP, all ligands were labelled with } 92% yield. Binding of the Ga-68-ligand complexes on hydroxyapatite was analysed to evaluate the effect of the number of the phosphorus acid groups on adsorption parameters. Adsorption of Ga-68-EDTMP and Ga-68-DOTP was } 83%. For the Ga-68-NOTA-phosphonates an increasing binding with increasing number of phosphonate groups was observed but was still lower than Ga-68-DOTP and Ga-68-EDTMP. mu-PET studies in vivo were performed with Ga-68-EDTMP and Ga-68-DOTP with Wistar rats. While Ga-68-EDTMP-PET showed uptake on bone structures, an excess amount of the ligand (} 1.5 mg EDTMP/kg body weight) had to be used, otherwise the Ga-68(3+) a is released from the complex and forms gallium hydroxide or it is transchelated to Ga-68-transferrin. As a result, the main focus of further phosphonate structures has to be on complex formation in high radiochemical yields with macrocyclic ligands with phosphonate groups that are not required for complexing Ga-68.
- Tc-99m-phosphonate structures are well established tracers for bone tumour imaging. Our objective was to investigate different Ga-68-labelled phosphonate ligands concerning labelling kinetics, binding to hydroxyapatite and bone imaging using mu-PET. Seven macrocyclic phosphorus-containing ligands and EDTMP were labelled in nanomolar scale with n.c.a. Ga-68 in Na-HEPES buffer at pH similar to 4. Except for DOTP, all ligands were labelled with } 92% yield. Binding of the Ga-68-ligand complexes on hydroxyapatite was analysed to evaluate the effect of the number of the phosphorus acid groups on adsorption parameters. Adsorption of Ga-68-EDTMP and Ga-68-DOTP was } 83%. For the Ga-68-NOTA-phosphonates an increasing binding with increasing number of phosphonate groups was observed but was still lower than Ga-68-DOTP and Ga-68-EDTMP. mu-PET studies in vivo were performed with Ga-68-EDTMP and Ga-68-DOTP with Wistar rats. While Ga-68-EDTMP-PET showed uptake on bone structures, an excess amount of the ligand (} 1.5 mg EDTMP/kg body weight) had to be used, otherwise the Ga-68(3+) a is released from the complex and forms gallium hydroxide or it is transchelated to Ga-68-transferrin. As a result, the main focus of further phosphonate structures has to be on complex formation in high radiochemical yields with macrocyclic ligands with phosphonate groups that are not required for complexing Ga-68. (en)
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| Title
| - Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism
- Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism (en)
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| skos:prefLabel
| - Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism
- Comparison of different phosphorus-containing ligands complexing Ga-68 for PET-imaging of bone metabolism (en)
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| skos:notation
| - RIV/00216208:11310/11:10089979!RIV12-MSM-11310___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11310/11:10089979
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - protonation; hydroxyapatite; pre-vivo; pain palliation; potential agent; nuclear magnetic-resonance (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Fellner, M.
- Geraldes, Carlos F. G. C.
- Kovacs, Z.
- Loktionova, N. S.
- Lukeš, Ivan
- Riss, P.
- Rösch, Frank
- Thews, O.
- Zhernosekov, K. P.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
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| http://localhost/t...ganizacniJednotka
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