About: Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Both Mycoplasma hominis and Trichomonas vaginalis utilize arginine as an energy source via the arginine dihydrolase (ADH) pathway. It has been previously demonstrated that M. hominis forms a stable intracellular relationship with I vaginalis; hence, in this study we examined the interaction of two localized ADH pathways by comparing T. vaginalis strain SS22 with the laboratory-generated T. vaginalis strain SS22-MOZ2 infected with M. hominis MOZ2. The presence of M. hominis resulted in an approximately 16-fold increase in intracellular ornithine and a threefold increase in putrescine, compared with control T vaginalis cultures. No change in the activity of enzymes of the ADH pathway could be demonstrated in SS22-MOZ2 compared with the parent SS22, and the increased production of ornithine could be attributed to the presence of M. hominis. Using metabolic flow analysis it was determined that the elasticity of enzymes of the ADH pathway in SS22-MOZ2 was unchanged compared with the parent SS22; however, the elasticity of ornithine decarboxylase (ODC) in SS22 was small, and it was doubled in SS22-MOZ2 cells. The potential benefit of this relationship to both T. vaginalis and M. hominis is discussed. Both Mycoplasma hominis and Trichomonas vaginalis utilize arginine as an energy source via the arginine dihydrolase (ADH) pathway. It has been previously demonstrated that M. hominis forms a stable intracellular relationship with I vaginalis; hence, in this study we examined the interaction of two localized ADH pathways by comparing T. vaginalis strain SS22 with the laboratory-generated T. vaginalis strain SS22-MOZ2 infected with M. hominis MOZ2. The presence of M. hominis resulted in an approximately 16-fold increase in intracellular ornithine and a threefold increase in putrescine, compared with control T vaginalis cultures. No change in the activity of enzymes of the ADH pathway could be demonstrated in SS22-MOZ2 compared with the parent SS22, and the increased production of ornithine could be attributed to the presence of M. hominis. Using metabolic flow analysis it was determined that the elasticity of enzymes of the ADH pathway in SS22-MOZ2 was unchanged compared with the parent SS22; however, the elasticity of ornithine decarboxylase (ODC) in SS22 was small, and it was doubled in SS22-MOZ2 cells. The potential benefit of this relationship to both T. vaginalis and M. hominis is discussed. (en)
Title	Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis (en)
skos:prefLabel	Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis Arginine metabolism in Trichomonas vaginalis infected with Mycoplasma hominis (en)
skos:notation	RIV/00216208:11310/10:10108838!RIV12-AV0-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA501110631), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Tachezy, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	247716
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10108838
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CELLS; SEQUENCE; MECHANISM; GIARDIA; ENZYMES; DEIMINASE; NITRIC-OXIDE; DIHYDROLASE PATHWAY (en)
http://linked.open.../riv/klicoveSlovo	NITRIC-OXIDE CELLS MECHANISM SEQUENCE DEIMINASE DIHYDROLASE PATHWAY GIARDIA ENZYMES
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D8AEA764D1A1]
http://linked.open...i/riv/nazevZdroje	Microbiology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Evolution and biogenesis of mitochondria-related organelles: hydrogenosomes and mitosomes
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	156
http://linked.open...iv/tvurceVysledku	Tachezy, Jan Fiori, Pier L. Morada, Mary Rappelli, Paola Yarlett, Nigel Dessi, Daniele Lam, Brian Manzur, Mafruha Tan, Cho
http://linked.open...ain/vavai/riv/wos	000285806200022
http://linked.open...n/vavai/riv/zamer	Signaling and cellular response mechanisms
issn	1350-0872
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1099/mic.0.042192-0
http://localhost/t...ganizacniJednotka	11310

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