About: Ambiguous decoding of the CUG codon alters the functionality of the Candida albicans translation initiation factor 4E

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About: Ambiguous decoding of the CUG codon alters the functionality of the Candida albicans translation initiation factor 4E Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The opportunistic human pathogen Candida albicans is the only known eukaryotic organism with the ability to survive defects in mRNA capping, which suggests unique features of its eIF4E protein. Here, we provide the first experimental evidence of the function of the C. albicans putative gene orf19.7626 as an eIF4E protein. We also show that Ca4ELeu116 and Ca4ESer116 protein variants, both of which occur naturally in C. albicans due to the ambiguous decoding of the CUG116 codon, display different sensitivities to elevated temperature. Our results clearly point to the importance of the S4-H4 loop for the function of the Ca4E translation initiation factor, and suggest the possible regulatory role of the codon-reading ambiguity within this loop in C. albicans. We proved Saccharomyces cerevisiae as a useful tool organism for studies of C. albicans translation initiation apparatus. The opportunistic human pathogen Candida albicans is the only known eukaryotic organism with the ability to survive defects in mRNA capping, which suggests unique features of its eIF4E protein. Here, we provide the first experimental evidence of the function of the C. albicans putative gene orf19.7626 as an eIF4E protein. We also show that Ca4ELeu116 and Ca4ESer116 protein variants, both of which occur naturally in C. albicans due to the ambiguous decoding of the CUG116 codon, display different sensitivities to elevated temperature. Our results clearly point to the importance of the S4-H4 loop for the function of the Ca4E translation initiation factor, and suggest the possible regulatory role of the codon-reading ambiguity within this loop in C. albicans. We proved Saccharomyces cerevisiae as a useful tool organism for studies of C. albicans translation initiation apparatus. (en)
Title	Ambiguous decoding of the CUG codon alters the functionality of the Candida albicans translation initiation factor 4E Ambiguous decoding of the CUG codon alters the functionality of the Candida albicans translation initiation factor 4E (en)
skos:prefLabel	Ambiguous decoding of the CUG codon alters the functionality of the Candida albicans translation initiation factor 4E Ambiguous decoding of the CUG codon alters the functionality of the Candida albicans translation initiation factor 4E (en)
skos:notation	RIV/00216208:11310/10:10082589!RIV11-MSM-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LA10023), P(LC06066), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Feketová, Zuzana Mašek, Tomáš Pospíšek, Martin Vopálenský, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	246093
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10082589
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	factor; initiation; translation; albicans; Candida; the; functionality; the; alters; codon; CUG; the; decoding; Ambiguous (en)
http://linked.open.../riv/klicoveSlovo	factor codon Candida decoding initiation the translation functionality Ambiguous CUG albicans alters
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A6C26BE420DE]
http://linked.open...i/riv/nazevZdroje	Fems Yeast Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Increasing participation of the Czech scientists in activities of the international scientific societies - The RNA Society, SGM and FEMS Center for Environmental Microbiology
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Mašek, Tomáš Pospíšek, Martin Vopálenský, Václav Feketová, Zuzana
http://linked.open...ain/vavai/riv/wos	000279734100007
http://linked.open...n/vavai/riv/zamer	Signaling and cellular response mechanisms
issn	1567-1356
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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