About: Measurement of Recent Exposure to Phlebotomus argentipes, the Vector of Indian Visceral Leishmaniasis, by Using Human Antibody Responses to Sand Fly Saliva     Goto   Sponge   NotDistinct   Permalink

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Description
  • Antibody (IgG) responses to the saliva of Phlebotomus argentipes were investigated using serum samples from regions of India endemic and non-endemic for visceral leishmaniasis (VL). By pre-adsorbing the sera against the saliva of the competing human-biting but non-VL vector P.papatasi. we significantly improved the specificity of a P.argentipes saliva enzyme-linked immunosorbent assay. Using this method, we observed a statistically significant correlation between antibodies to P argenitpes saliva and the average indoor density of female sand flies. Additionally, the method was able to detect recent changes in vector exposure when sera from VL patients were assayed before, during, and after hospitalization and protected from sand fly bites under untreated bed nets. Collectively, these results highlight the utility of antibodies to P.argentipes saliva as an important tool to evaluate VL vector control programs.
  • Antibody (IgG) responses to the saliva of Phlebotomus argentipes were investigated using serum samples from regions of India endemic and non-endemic for visceral leishmaniasis (VL). By pre-adsorbing the sera against the saliva of the competing human-biting but non-VL vector P.papatasi. we significantly improved the specificity of a P.argentipes saliva enzyme-linked immunosorbent assay. Using this method, we observed a statistically significant correlation between antibodies to P argenitpes saliva and the average indoor density of female sand flies. Additionally, the method was able to detect recent changes in vector exposure when sera from VL patients were assayed before, during, and after hospitalization and protected from sand fly bites under untreated bed nets. Collectively, these results highlight the utility of antibodies to P.argentipes saliva as an important tool to evaluate VL vector control programs. (en)
Title
  • Measurement of Recent Exposure to Phlebotomus argentipes, the Vector of Indian Visceral Leishmaniasis, by Using Human Antibody Responses to Sand Fly Saliva
  • Measurement of Recent Exposure to Phlebotomus argentipes, the Vector of Indian Visceral Leishmaniasis, by Using Human Antibody Responses to Sand Fly Saliva (en)
skos:prefLabel
  • Measurement of Recent Exposure to Phlebotomus argentipes, the Vector of Indian Visceral Leishmaniasis, by Using Human Antibody Responses to Sand Fly Saliva
  • Measurement of Recent Exposure to Phlebotomus argentipes, the Vector of Indian Visceral Leishmaniasis, by Using Human Antibody Responses to Sand Fly Saliva (en)
skos:notation
  • RIV/00216208:11310/10:10081196!RIV11-MSM-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC06009), Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 270033
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/10:10081196
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • MARKER; CHAGASI; GLAND ANTIGENS; IMMUNE-RESPONSE; LUTZOMYIA-LONGIPALPIS SALIVA (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [AE7D383586F2]
http://linked.open...i/riv/nazevZdroje
  • American Journal of Tropical Medicine and Hygiene
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 82
http://linked.open...iv/tvurceVysledku
  • Volf, Petr
  • Kumar, Rajiv
  • Volfová, Věra
  • Boelaert, Marleen
  • Gidwani, Kamlesh
  • Picado, Albert
  • Rijal, Suman
  • Sundar, Shyam
  • Hostomská, Jitka
  • Clements, Meredith
  • Das, Murari
  • Das, Pradeep
  • Davies, Clive R.
  • Dinesh, Diwakar
  • Hamilton, Gordno
  • Kumar, Vijay
  • Müller, Ingrid
  • Rogers, Matthew E.
http://linked.open...ain/vavai/riv/wos
  • 000277406500010
http://linked.open...n/vavai/riv/zamer
issn
  • 0002-9637
number of pages
http://localhost/t...ganizacniJednotka
  • 11310
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