About: The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica

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About: The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The metabolic transformation of mitochondria in distinct lineages of eukaryotes created proteomes ranging from thousands of proteins to what appear to be a much simpler scenario. In the case of Entamoeba histolytica, tiny mitochondria known as mitosomes have undergone extreme reduction. Only recently a single complete metabolic pathway of sulfate activation has been identified in these organelles. The E. histolytica mitosomes do not produce ATP needed for the sulfate activation pathway and for three molecular chaperones, Cpn60, Cpn10 and mtHsp70. We used a hidden Markov model (HMM) based search of the E. histolytica genome sequence to discover candidate (i) mitosomal phosphate carrier complementing the activity of the ADP/ATP carrier and (ii) membrane-located components of the protein import machinery that includes the outer membrane translocation channel Tom40 and membrane assembly protein Sam50. The metabolic transformation of mitochondria in distinct lineages of eukaryotes created proteomes ranging from thousands of proteins to what appear to be a much simpler scenario. In the case of Entamoeba histolytica, tiny mitochondria known as mitosomes have undergone extreme reduction. Only recently a single complete metabolic pathway of sulfate activation has been identified in these organelles. The E. histolytica mitosomes do not produce ATP needed for the sulfate activation pathway and for three molecular chaperones, Cpn60, Cpn10 and mtHsp70. We used a hidden Markov model (HMM) based search of the E. histolytica genome sequence to discover candidate (i) mitosomal phosphate carrier complementing the activity of the ADP/ATP carrier and (ii) membrane-located components of the protein import machinery that includes the outer membrane translocation channel Tom40 and membrane assembly protein Sam50. (en)
Title	The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica (en)
skos:prefLabel	The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica (en)
skos:notation	RIV/00216208:11310/10:10080557!RIV11-MSM-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC07032), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Doležal, Pavel Šedinová, Miroslava Tachezy, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	257514
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10080557
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	yeast mitochondria; precursor proteins; remnant organelles; hydrogenosomes contain; saccharomyces-cerevisiae; encephalitozoon-cuniculi; microsporidian mitosomes; dictyostelium-discoideum; outer-membrane; Hidden markov-models (en)
http://linked.open.../riv/klicoveSlovo	saccharomyces-cerevisiae Hidden markov-models dictyostelium-discoideum encephalitozoon-cuniculi hydrogenosomes contain microsporidian mitosomes outer-membrane precursor proteins remnant organelles yeast mitochondria
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2566C1A705B6]
http://linked.open...i/riv/nazevZdroje	PLoS Pathogens
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Functional Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Doležal, Pavel Lithgow, Trevor Tachezy, Jan Šedinová, Miroslava Bachmann, Anna Bruchhaus, Iris Dagley, Michael J. Foo, Jung Hock Kono, Maya Likic, Vladimir A. Wolynec, Peter
http://linked.open...ain/vavai/riv/wos	000277720400022
http://linked.open...n/vavai/riv/zamer	Signaling and cellular response mechanisms
issn	1553-7366
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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