About: Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents

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About: Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	RP-HPLC and non-aqueous CZE methods were evaluated for qualitative and quantitative analysis of esterified macrocyclic compounds of the DOTA family (DOTA = 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic: acid). This group of compounds represents important reaction intermediates in synthesis of magnetic resonance contrast agents. Calibration curves in the concentration range from 1.0 x 10(-5) to 1.0 x 10(-3) mol/L were plotted and the experimental data were critically compared in terms of their repeatability, linearity, LOD and LOQ. The optimized methods were successfully applied to the analysis of a real reaction mixture without any further pretreatment. RP-HPLC and non-aqueous CZE methods were evaluated for qualitative and quantitative analysis of esterified macrocyclic compounds of the DOTA family (DOTA = 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic: acid). This group of compounds represents important reaction intermediates in synthesis of magnetic resonance contrast agents. Calibration curves in the concentration range from 1.0 x 10(-5) to 1.0 x 10(-3) mol/L were plotted and the experimental data were critically compared in terms of their repeatability, linearity, LOD and LOQ. The optimized methods were successfully applied to the analysis of a real reaction mixture without any further pretreatment. (en)
Title	Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents (en)
skos:prefLabel	Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents Comparison of HPLC and CZE methods for analysis of DOTA-like esters - reaction intermediates in synthesis of magnetic resonance contrast agents (en)
skos:notation	RIV/00216208:11310/10:10056957!RIV11-MSM-11310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	4-5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Křížek, Tomáš Bosáková, Zuzana Coufal, Pavel Kubíček, Vojtěch Kubíčková, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	251448
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10056957
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	acid; plasma; instrumentation; lanthanide complexes; liquid-chromatographic determination (en)
http://linked.open.../riv/klicoveSlovo	lanthanide complexes acid instrumentation plasma liquid-chromatographic determination
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[04A91DFF990F]
http://linked.open...i/riv/nazevZdroje	Journal of Separation Science
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Bosáková, Zuzana Coufal, Pavel Kubíček, Vojtěch Křížek, Tomáš Hamplová, Anna
http://linked.open...ain/vavai/riv/wos	000276573800027
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1615-9306
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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