About: Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates

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About: Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In magnetic resonance imaging (MRI), paramagnetic complexes are utilized as contrast agents. Much attention has been paid to the development of new contrast agents responsive to pH, temperature or concentration of various components of body liquids. We report a new type of MRI probe sensing the concentrations of calcium and magnesium in biological media. The ligand do3ap(BP) combines a dota-like chelator with a bisphosphonate group. In the complex, the Gd(III) ion is entrapped in the macrocyclic cavity whereas the bisphosphonate group is not coordinated and therefore is available for coordination with endogenous metal ions. In the presence of metal ions, Gd-do3ap(BP) appears to show formation of coordination oligomers leading to an unprecedented increase in r(1) up to 200-500%. The extremely high relaxivity response makes this type of compound interesting for further studies as MRI ion-responsive probes for biomedical research. In magnetic resonance imaging (MRI), paramagnetic complexes are utilized as contrast agents. Much attention has been paid to the development of new contrast agents responsive to pH, temperature or concentration of various components of body liquids. We report a new type of MRI probe sensing the concentrations of calcium and magnesium in biological media. The ligand do3ap(BP) combines a dota-like chelator with a bisphosphonate group. In the complex, the Gd(III) ion is entrapped in the macrocyclic cavity whereas the bisphosphonate group is not coordinated and therefore is available for coordination with endogenous metal ions. In the presence of metal ions, Gd-do3ap(BP) appears to show formation of coordination oligomers leading to an unprecedented increase in r(1) up to 200-500%. The extremely high relaxivity response makes this type of compound interesting for further studies as MRI ion-responsive probes for biomedical research. (en)
Title	Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates (en)
skos:prefLabel	Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates (en)
skos:notation	RIV/00216208:11310/10:10051989!RIV11-GA0-11310___
http://linked.open...avai/riv/aktivita	P R Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1056), P(KAN201110651), P(OC 179), R, Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vitha, Tomáš Kotek, Jan Lukeš, Ivan Hermann, Petr Kubíček, Vojtěch
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	293136
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10051989
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	responsive agents; bisphosphonate; gadolinium complexes; MRI (en)
http://linked.open.../riv/klicoveSlovo	gadolinium complexes responsive agents bisphosphonate MRI
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3B228D323E9E]
http://linked.open...i/riv/nazevZdroje	Contrast Media and Molecular Imaging
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Macrocyclic ligands suitable for development of new radiopharmaceuticals based on metal isotopes http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20179 Combined contrast agents for molecular MR imaging
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Hermann, Petr Kotek, Jan Kubíček, Vojtěch Lukeš, Ivan Vitha, Tomáš Peters, Joop A. Muller, Robert N. Vander Elst, Luce
http://linked.open...ain/vavai/riv/wos	000283641900006
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1555-4309
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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