About: Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/ phosphinic acid pendant arm

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About: Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/ phosphinic acid pendant arm Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This work intends to investigate samarium and holmium complexes with a set of H(4)dota-analogues bearing methylphosphonate/methylphosphinic acid pendant arms (H(5)do3ap, H(5)do3ap(PrA) and H(4)do3aP(ABn)) as new bifunctional ligands for radiolanthanide targeted therapy. Radiolanthanide complexes of these ligands were prepared and evaluated as potential therapeutical agents. Thermodynamic solution studies were also performed to get a better insight on the radiochemical results. This work intends to investigate samarium and holmium complexes with a set of H(4)dota-analogues bearing methylphosphonate/methylphosphinic acid pendant arms (H(5)do3ap, H(5)do3ap(PrA) and H(4)do3aP(ABn)) as new bifunctional ligands for radiolanthanide targeted therapy. Radiolanthanide complexes of these ligands were prepared and evaluated as potential therapeutical agents. Thermodynamic solution studies were also performed to get a better insight on the radiochemical results. (en)
Title	Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/ phosphinic acid pendant arm Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/ phosphinic acid pendant arm (en)
skos:prefLabel	Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/ phosphinic acid pendant arm Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/ phosphinic acid pendant arm (en)
skos:notation	RIV/00216208:11310/10:10051874!RIV11-GA0-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1056), P(OC 179), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hermann, Petr Kubíček, Vojtěch
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	250558
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/10:10051874
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DOTA analog; potential agents; multiple-myeloma; Ho-166 complexes; lanthanide(III) complexes; water exchange-rate; absorbed dose estimation; skeletal targeted radiotherapy; MRI contrast agents; bone pain palliation (en)
http://linked.open.../riv/klicoveSlovo	multiple-myeloma lanthanide(III) complexes MRI contrast agents water exchange-rate DOTA analog Ho-166 complexes absorbed dose estimation bone pain palliation potential agents skeletal targeted radiotherapy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DF02E64FB40A]
http://linked.open...i/riv/nazevZdroje	Journal of Labelled Compounds and Radiopharmaceuticals
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Macrocyclic ligands suitable for development of new radiopharmaceuticals based on metal isotopes http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20179
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Hermann, Petr Kubíček, Vojtěch Santos, Isabel Campello, Paula Gano, Lurdes Lacerda, Sara Marques, Fernanda
http://linked.open...ain/vavai/riv/wos	000275388100007
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	0362-4803
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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