About: Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase

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About: Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1021/jm8015798
Description	In this study, we prepared a new series of betaine-homocysteine S-methyltransferase (BHMT) inhibitors. The inhibitors were designed to mimic the hypothetical transition state of BHMT substrates, betaine and homocysteine, and consisted of analogues with NH, N(CH3), or N(CH3)2 groups separated from the homocysteine sulfur atom by a methylene, ethylene, or a propylene spacer. The inhibition results evoke questions about putative conformational changes of BHMT upon the binding of the substrates/products and inhibitors. In this study, we prepared a new series of betaine-homocysteine S-methyltransferase (BHMT) inhibitors. The inhibitors were designed to mimic the hypothetical transition state of BHMT substrates, betaine and homocysteine, and consisted of analogues with NH, N(CH3), or N(CH3)2 groups separated from the homocysteine sulfur atom by a methylene, ethylene, or a propylene spacer. The inhibition results evoke questions about putative conformational changes of BHMT upon the binding of the substrates/products and inhibitors. (en)
Title	Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase (en)
skos:prefLabel	Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase Structure-Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase (en)
skos:notation	RIV/00216208:11310/09:10109553!RIV12-MSM-11310___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0508), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kožíšek, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	344229
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/09:10109553
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	inhibitor; methionine; homocysteine; betain; BHMT (en)
http://linked.open.../riv/klicoveSlovo	homocysteine methionine BHMT betain inhibitor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F9C04CADA799]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Buděšínský, Miloš Kožíšek, Milan Rosenberg, Ivan Šanda, Miloslav Vaněk, Václav Hančlová, Ivona Jiráček, Jiří Mládková, Jana Kabeleová, Petra Garrow, Timothy A. Koutmos, Markos
http://linked.open...ain/vavai/riv/wos	000267180600006
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	0022-2623
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/jm8015798
http://localhost/t...ganizacniJednotka	11310

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