About: The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells

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About: The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The molecular mechanism of DNA-mediated ellipticine action in human neuroblastoma IMR-32, UKF-NB-3 and UKF-NB-4 cancer cell lines was investigated. Treatment of neuroblastoma cells with ellipticine resulted in apoptosis induction, which was verified by the appearance of DNA fragmentation, and in inhibition of cell growth. These effects were associated with formation of two covalent ellipticine-derived DNA adducts, identical to those formed by the cytochrome P450- and peroxidase-mediated ellipticine metabolites, 13-hydroxy- and 12-hydroxyellipticine. The results demonstrate that among the multiple modes of ellipticine antitumor action, formation of covalent DNA adducts by ellipticine is the predominant mechanism of cytotoxicity to neuroblastoma cells. The molecular mechanism of DNA-mediated ellipticine action in human neuroblastoma IMR-32, UKF-NB-3 and UKF-NB-4 cancer cell lines was investigated. Treatment of neuroblastoma cells with ellipticine resulted in apoptosis induction, which was verified by the appearance of DNA fragmentation, and in inhibition of cell growth. These effects were associated with formation of two covalent ellipticine-derived DNA adducts, identical to those formed by the cytochrome P450- and peroxidase-mediated ellipticine metabolites, 13-hydroxy- and 12-hydroxyellipticine. The results demonstrate that among the multiple modes of ellipticine antitumor action, formation of covalent DNA adducts by ellipticine is the predominant mechanism of cytotoxicity to neuroblastoma cells. (en)
Title	The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells (en)
skos:prefLabel	The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells The mechanism of cytotoxicity and DNA adduct formation by the anticancer drug ellipticine in human neuroblastoma cells (en)
skos:notation	RIV/00216208:11310/09:10001346!RIV10-MZ0-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0505), P(GA203/06/0329), P(NR9522), Z(MSM0021620813)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Martínek, Václav Stiborová, Marie Poljaková, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	325185
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/09:10001346
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Environmental-pollutant 3-nitrobenzanthrone; human cytochrome-p450 enzymes; carcinogen aristolochic acid; prostaglandin-h synthase; human metabolite; cycle arrest; cancer-cells; deoxyguanosine adducts; liver-microsomes; in-vivo (en)
http://linked.open.../riv/klicoveSlovo	prostaglandin-h synthase carcinogen aristolochic acid deoxyguanosine adducts in-vivo cancer-cells liver-microsomes Environmental-pollutant 3-nitrobenzanthrone cycle arrest human cytochrome-p450 enzymes human metabolite
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[50FB14FE4C20]
http://linked.open...i/riv/nazevZdroje	Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of targeted therapeutic drugs Potentiation of cytostatics effects by valproic acid Study on mechanism of antineoplastic action of an anticancer drug ellipticine
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	77
http://linked.open...iv/tvurceVysledku	Eckschlager, Tomáš Frei, Eva Hraběta, Jan Kizek, René Martínek, Václav Poljaková, Jitka Stiborová, Marie Smutný, Svatopluk Hřebačková, Jana
http://linked.open...ain/vavai/riv/wos	000265197000003
http://linked.open...n/vavai/riv/zamer	The Molecular Basis of Childhood Malignancies and Therapeutic Applications
issn	0006-2952
number of pages	14 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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