About: Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine     Goto   Sponge   NotDistinct   Permalink

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Description
  • A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps.
  • A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps. (en)
Title
  • Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine
  • Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine (en)
skos:prefLabel
  • Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine
  • Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine (en)
skos:notation
  • RIV/00216208:11310/09:10000814!RIV10-GA0-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP203/09/P193), Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika
  • 17
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 317155
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/09:10000814
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Highly; enantioselective; organocatalytic; synthesis; piperidines.; Formal; synthesis; (-)-Paroxetine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [1A300E9CD78E]
http://linked.open...i/riv/nazevZdroje
  • Tetrahedron Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 50
http://linked.open...iv/tvurceVysledku
  • Císařová, Ivana
  • Veselý, Jan
  • Rios, Ramon
  • Moyano, Albert
  • Schimer, Jiří
  • Valero, Guillem
http://linked.open...ain/vavai/riv/wos
  • 000264954000017
http://linked.open...n/vavai/riv/zamer
issn
  • 0040-4039
number of pages
http://localhost/t...ganizacniJednotka
  • 11310
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