About: A role of biotransformation enzymes in the Development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions difficult answers

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About: A role of biotransformation enzymes in the Development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions difficult answers Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The most important human enzymes activating aristolochic acid I (AAI) by simple nitroreduction in vitro are hepatic and renal cytosolic NAD(P)H:quinone oxidoreductase, hepatic microsomal cytochrome P450 (CYP) 1A2 and renal microsomal NADPH:CYP reductase, besides cyclooxygenase, which is highly expressed in urothelial tissue. Despite extensive research, contribution of most of these enzymes to the development of AAN and BEN diseases is still unknown. Hepatic CYP enzymes were found to detoxicate AAI to AAIa in mice, and thereby protect the kidney from injury. CYP enzymes of a 1A subfamily seem to play the most important role in this process in mouse liver. Likewise, among human CYP enzymes, CYP1A1 and 1A2 were found to be the most efficient enzymes participating in AAI oxidation to AAIa in vitro. The most important human enzymes activating aristolochic acid I (AAI) by simple nitroreduction in vitro are hepatic and renal cytosolic NAD(P)H:quinone oxidoreductase, hepatic microsomal cytochrome P450 (CYP) 1A2 and renal microsomal NADPH:CYP reductase, besides cyclooxygenase, which is highly expressed in urothelial tissue. Despite extensive research, contribution of most of these enzymes to the development of AAN and BEN diseases is still unknown. Hepatic CYP enzymes were found to detoxicate AAI to AAIa in mice, and thereby protect the kidney from injury. CYP enzymes of a 1A subfamily seem to play the most important role in this process in mouse liver. Likewise, among human CYP enzymes, CYP1A1 and 1A2 were found to be the most efficient enzymes participating in AAI oxidation to AAIa in vitro. (en)
Title	A role of biotransformation enzymes in the Development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions difficult answers A role of biotransformation enzymes in the Development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions difficult answers (en)
skos:prefLabel	A role of biotransformation enzymes in the Development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions difficult answers A role of biotransformation enzymes in the Development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions difficult answers (en)
skos:notation	RIV/00216208:11310/09:10000249!RIV10-GA0-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/09/0472), Z(MSM0021620808)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Stiborová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	301564
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/09:10000249
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Balkan endemic nephropathy; chinese herbs nephropathy; cytochromes p450 1a1; gene-expression profiles; prostaglandin-h synthase; dna adduct formation; reductive activation; metabolic-activation; risk-factor; nad(p)h-quinone oxidoreductase (en)
http://linked.open.../riv/klicoveSlovo	dna adduct formation prostaglandin-h synthase risk-factor metabolic-activation gene-expression profiles Balkan endemic nephropathy chinese herbs nephropathy cytochromes p450 1a1 nad(p)h-quinone oxidoreductase reductive activation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[BF272F40562E]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers Medical Faculty University Palacky Olomouc Czech Republic
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on participation of biotransformation enzymes in development of renal injury and urothelial cancer mediated by aristolochic acid
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	153
http://linked.open...iv/tvurceVysledku	Frei, Eva Stiborová, Marie Arlt, Volker Schmeiser, Heinz
http://linked.open...ain/vavai/riv/wos	000265639300002
http://linked.open...n/vavai/riv/zamer	Molekulárně biologické, genetické a epigenetické aspekty vzniku a rozvoje modelových tumorů dospělého věku. Význam pro epidemiologii, časnou diagnostiku a léčbu
issn	1213-8118
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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