About: The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis     Goto   Sponge   NotDistinct   Permalink

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  • The identification of mitosomes in Giardia generated significant debate on the evolutionary origin of these organelles, whether they were highly reduced mitochondria or the product of a unique endosymbiotic event in an amitochondrial organism. As the protein import pathway is a defining characteristic of mitochondria, we sought to discover a TOM (translocase in the outer mitochondrial membrane) complex in Giardia. A Hidden Markov model search of the Giardia genome identified a Tom40 homologous sequence (GiTom40), where Tom40 is the protein translocation channel of the TOM complex. The GiTom40 protein is located in the membrane of mitosomes in a similar to 200-kDa TOM complex. As Tom40 was derived in the development of mitochondria to serve as the protein import channel in the outer membrane, its presence in Giardia evidences the mitochondrial ancestry of mitosomes.
  • The identification of mitosomes in Giardia generated significant debate on the evolutionary origin of these organelles, whether they were highly reduced mitochondria or the product of a unique endosymbiotic event in an amitochondrial organism. As the protein import pathway is a defining characteristic of mitochondria, we sought to discover a TOM (translocase in the outer mitochondrial membrane) complex in Giardia. A Hidden Markov model search of the Giardia genome identified a Tom40 homologous sequence (GiTom40), where Tom40 is the protein translocation channel of the TOM complex. The GiTom40 protein is located in the membrane of mitosomes in a similar to 200-kDa TOM complex. As Tom40 was derived in the development of mitochondria to serve as the protein import channel in the outer membrane, its presence in Giardia evidences the mitochondrial ancestry of mitosomes. (en)
Title
  • The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis
  • The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis (en)
skos:prefLabel
  • The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis
  • The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis (en)
skos:notation
  • RIV/00216208:11310/09:10000041!RIV10-MSM-11310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 337268
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11310/09:10000041
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • The; Protein; Import; Channel; the; Outer; Mitosomal; Membrane; Giardia; intestinalis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [4E9BEA7339F0]
http://linked.open...i/riv/nazevZdroje
  • MOLECULAR BIOLOGY AND EVOLUTION
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 26
http://linked.open...iv/tvurceVysledku
  • Doležal, Pavel
  • Lithgow, Trevor
  • Tachezy, Jan
  • Šmíd, Ondřej
  • Dagley, Michael J.
  • Likic, Vladimir A.
  • Buchanan, Susan K.
  • Purcell, Anthony W.
http://linked.open...ain/vavai/riv/wos
  • 000269001500002
http://linked.open...n/vavai/riv/zamer
issn
  • 0737-4038
number of pages
http://localhost/t...ganizacniJednotka
  • 11310
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