About: Investigation of Anticancer and Antiviral Properties of Selected Aroma samples

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://hosting.workplace.cz/DZS/Aktion.nsf/49d935dd86ccec96c1256c8e0045806d/472ccd25e068bdb2c12573a100385aaa/$FILE/50p16-Artikel.pdf
Description	Anti-tumor and antiviral activities of various aroma samples, including cinnamic acid, P-caryophyllene, caryophyllene oxide, nerolidol (synthetic and natural samples), trans, trans-famesol, famesol (isomeric mixture), longifolene, geranic acid and a farnesol-rich ylang-fraction were investigated using HeLa and Jurkat cell lines. Using a CytoTox-96 (R)-Assay we observed strong anti-tumor effects of natural- and synthetic nerolidol-samples at concentrations less than 5 mu M. Furthermore, synthetic nerolidol reduced the number of HeLa and Jurkat cells to 50% (CC(50)) at concentrations which were more than ten times lower compared with the effective doses required to achieve 50% cytotoxicity (ED(50)). Antiviral studies were performed to investigate inhibitory effects of the compounds on mouse polyomavirus propagation in 3T6 cells. Remarkable inhibition of viral activity was demonstrated by synthetic nerolidol at CC(50) 3.2 +/- 1.5 mu M and natural nerolidol at CC(50) 1.2 +/- 0.4 mu M All other compounds, however, did not show any inhibition against this virus. Anti-tumor and antiviral activities of various aroma samples, including cinnamic acid, P-caryophyllene, caryophyllene oxide, nerolidol (synthetic and natural samples), trans, trans-famesol, famesol (isomeric mixture), longifolene, geranic acid and a farnesol-rich ylang-fraction were investigated using HeLa and Jurkat cell lines. Using a CytoTox-96 (R)-Assay we observed strong anti-tumor effects of natural- and synthetic nerolidol-samples at concentrations less than 5 mu M. Furthermore, synthetic nerolidol reduced the number of HeLa and Jurkat cells to 50% (CC(50)) at concentrations which were more than ten times lower compared with the effective doses required to achieve 50% cytotoxicity (ED(50)). Antiviral studies were performed to investigate inhibitory effects of the compounds on mouse polyomavirus propagation in 3T6 cells. Remarkable inhibition of viral activity was demonstrated by synthetic nerolidol at CC(50) 3.2 +/- 1.5 mu M and natural nerolidol at CC(50) 1.2 +/- 0.4 mu M All other compounds, however, did not show any inhibition against this virus. (en)
Title	Investigation of Anticancer and Antiviral Properties of Selected Aroma samples Investigation of Anticancer and Antiviral Properties of Selected Aroma samples (en)
skos:prefLabel	Investigation of Anticancer and Antiviral Properties of Selected Aroma samples Investigation of Anticancer and Antiviral Properties of Selected Aroma samples (en)
skos:notation	RIV/00216208:11310/08:10112466!RIV12-MSM-11310___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Ryabchenko, Boris
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	373193
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/08:10112466
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	farnesol; nerolidol; cytotoxicity; anticancer; antiviral (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity antiviral anticancer farnesol nerolidol
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0E6D429E85C0]
http://linked.open...i/riv/nazevZdroje	Natural product communications
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Ryabchenko, Boris Elena, Tupoleva Erich, Schmidt Gerhard, Buchbauer Katrin, Wlcek Leopold, Jirovetz
http://linked.open...ain/vavai/riv/wos	000257678800012
http://linked.open...n/vavai/riv/zamer	New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1934-578X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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