About: Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.hindawi.com/journals/tswj/2014/703053/
Description	Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine epsilon-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase. The most active MtAlaDH inhibitor, 5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate, has an IC50 of 4.96 mu M and the best docking results. Other mycobacterial enzymes were mostly inhibited by some derivatives but at higher concentrations; isocitrate lyase showed the highest resistance to salicylanilide diethyl phosphates. Antimycobacterially active salicylanilide diethyl phosphates were evaluated to identify their potential drug target(s) for the inhibition of several mycobacterial enzymes, including isocitrate lyase, L-alanine dehydrogenase (MtAlaDH), lysine epsilon-aminotransferase, chorismate mutase, and pantothenate synthetase. The enzymes are related to the nongrowing state of Mycobacterium tuberculosis. Salicylanilide diethyl phosphates represent new candidates with significant inhibitory activity especially against L-alanine dehydrogenase. The most active MtAlaDH inhibitor, 5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate, has an IC50 of 4.96 mu M and the best docking results. Other mycobacterial enzymes were mostly inhibited by some derivatives but at higher concentrations; isocitrate lyase showed the highest resistance to salicylanilide diethyl phosphates. (en)
Title	Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes (en)
skos:prefLabel	Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes Salicylanilide Diethyl Phosphates as Potential Inhibitors of Some Mycobacterial Enzymes (en)
skos:notation	RIV/00216208:11160/14:10281951!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0235), P(EE2.3.30.0022)
http://linked.open...iv/cisloPeriodika	November
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Krátký, Martin Novotná, Eva Vinšová, Jarmila Komlóová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	43724
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281951
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pantothenate synthetase; chorismate mutase; lysine epsilon-aminotransferase; L-alanine dehydrogenase; isocitrate lyase; Mycobacterial enzyme; salicylanilide diethyl phosphates (en)
http://linked.open.../riv/klicoveSlovo	isocitrate lyase L-alanine dehydrogenase Mycobacterial enzyme chorismate mutase lysine epsilon-aminotransferase pantothenate synthetase salicylanilide diethyl phosphates
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[62A0DE565A2C]
http://linked.open...i/riv/nazevZdroje	The Scientific World Journal
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Establishment of Research Team Focused on Experimental and Applied Biopharmacy Support of establishment, development, and mobility of quality research teams at the Charles University
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	2014
http://linked.open...iv/tvurceVysledku	Krátký, Martin Novotná, Eva Vinšová, Jarmila Švarcová, Markéta Dharmarajan, Sriram Perumal, Yogeeswari Shalini, Saxena
issn	1537-744X
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2014/703053
http://localhost/t...ganizacniJednotka	11160

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