About: Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity

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About: Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pubget.com/paper/25115079
Description	Ongoing studies of Zephyranthes robusta resulted in the isolation of the lycorine-type alkaloid previously called carinatine and 10-O-demethylgalanthine. The NMR data given previously for this compound were revised and completed by two-dimensional H-1-H-1 and H-1-C-13 chemical shift correlation experiments. The name of the isolated compound was corrected to 9-O-demethylgalanthine in accordance with the currently used system of numbering of lycorine-type alkaloids. 9-O-Demethylgalanthine and galanthine, a previously isolated alkaloid from Z. robusta, were inactive in acetylcholinesterase/butyrylcholinesterase assays (IC50> 500 mu M), but showed important prolyl oligopeptidase inhibition activity. Ongoing studies of Zephyranthes robusta resulted in the isolation of the lycorine-type alkaloid previously called carinatine and 10-O-demethylgalanthine. The NMR data given previously for this compound were revised and completed by two-dimensional H-1-H-1 and H-1-C-13 chemical shift correlation experiments. The name of the isolated compound was corrected to 9-O-demethylgalanthine in accordance with the currently used system of numbering of lycorine-type alkaloids. 9-O-Demethylgalanthine and galanthine, a previously isolated alkaloid from Z. robusta, were inactive in acetylcholinesterase/butyrylcholinesterase assays (IC50> 500 mu M), but showed important prolyl oligopeptidase inhibition activity. (en)
Title	Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity (en)
skos:prefLabel	Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity Revised NMR Data for 9-O-Demethylgalanthine: an Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity (en)
skos:notation	RIV/00216208:11160/14:10281882!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP303/11/1907), S
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Šafratová, Marcela Kulhánková, Andrea Cahlíková, Lucie Macáková, Kateřina Opletal, Lubomír Kuneš, Jiří Novák, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	42623
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281882
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Prolyl oligopeptidase inhibition activity; 9-O-Demethylgalanthine; Amaryllidaceae; Zephyranthes robusta (en)
http://linked.open.../riv/klicoveSlovo	Zephyranthes robusta Amaryllidaceae 9-O-Demethylgalanthine Prolyl oligopeptidase inhibition activity
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[191B93579405]
http://linked.open...i/riv/nazevZdroje	Natural product communications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Hrabinová, Martina Kuneš, Jiří Cahlíková, Lucie Jun, Daniel Kulhánková, Andrea Macáková, Kateřina Opletal, Lubomír Novák, Zdeněk Šafratová, Marcela
http://linked.open...ain/vavai/riv/wos	000338095300014
issn	1934-578X
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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