About: Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0968089613010109
Description	A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5 mu mol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1 mu mol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs }= P1.95 mu mol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82 mu mol/L, but there is no direct correlation with MICs for mycobacteria. A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5 mu mol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1 mu mol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs }= P1.95 mu mol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82 mu mol/L, but there is no direct correlation with MICs for mycobacteria. (en)
Title	Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity (en)
skos:prefLabel	Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity (en)
skos:notation	RIV/00216208:11160/14:10281768!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.30.0022)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Kozic, Ján Krátký, Martin Buchta, Vladimír Mandíková, Jana Trejtnar, František Vinšová, Jarmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	43725
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281768
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Salicylanilide; In vitro antimycobacterial activity; In vitro antimicrobial activity; Cytotoxicity; Diethyl phosphate (en)
http://linked.open.../riv/klicoveSlovo	Diethyl phosphate Cytotoxicity In vitro antimycobacterial activity In vitro antimicrobial activity Salicylanilide
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[830812560CDC]
http://linked.open...i/riv/nazevZdroje	Bioorganic and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Support of establishment, development, and mobility of quality research teams at the Charles University
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Buchta, Vladimír Krátký, Martin Vinšová, Jarmila Mandíková, Jana Stolaříková, Jiřina Trejtnar, František Kozic, Ján
http://linked.open...ain/vavai/riv/wos	000329576400007
issn	0968-0896
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bmc.2013.12.016
http://localhost/t...ganizacniJednotka	11160

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