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Description
| - A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5 mu mol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1 mu mol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs }= P1.95 mu mol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82 mu mol/L, but there is no direct correlation with MICs for mycobacteria.
- A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5 mu mol/L. Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1 mu mol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs }= P1.95 mu mol/L), whereas their antifungal activity is significantly lower. The IC50 values for Hep G2 cells were within the range of 1.56-33.82 mu mol/L, but there is no direct correlation with MICs for mycobacteria. (en)
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Title
| - Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity
- Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity (en)
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skos:prefLabel
| - Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity
- Salicylanilide diethyl phosphates: Synthesis, antimicrobial activity and cytotoxicity (en)
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skos:notation
| - RIV/00216208:11160/14:10281768!RIV15-MSM-11160___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11160/14:10281768
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Salicylanilide; In vitro antimycobacterial activity; In vitro antimicrobial activity; Cytotoxicity; Diethyl phosphate (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Bioorganic and Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Buchta, Vladimír
- Krátký, Martin
- Vinšová, Jarmila
- Mandíková, Jana
- Stolaříková, Jiřina
- Trejtnar, František
- Kozic, Ján
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.bmc.2013.12.016
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http://localhost/t...ganizacniJednotka
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