About: Determination of pteridines in biological samples with an emphasis on their stability

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.future-science.com/doi/full/10.4155/bio.13.194
Description	Pteridines are a group of endogenous heterocyclic compounds whose concentrations in biological fluids may be increased in some disorders, such as infections, autoimmune disorders and cancer. In particular, pteridine concentrations in urine may represent promising noninvasive markers. However, their specificity requires further investigation. Pteridines can occur in three oxidation states with different stability. In order to enable the analysis of the unstable di- and tetra-hydroforms either an oxidation (mainly with iodine) or stabilization by reducing agents is applied. Due to the high polarity of pteridines, many analytical procedures employed ion-pair, ion-exchange or hydrophilic interaction liquid chromatography using mostly fluorescence detection. In the last decade, MS was found to be applicable. The objective of this Review is to show possibilities and different approaches in pteridine analysis in biological samples. Pteridines are a group of endogenous heterocyclic compounds whose concentrations in biological fluids may be increased in some disorders, such as infections, autoimmune disorders and cancer. In particular, pteridine concentrations in urine may represent promising noninvasive markers. However, their specificity requires further investigation. Pteridines can occur in three oxidation states with different stability. In order to enable the analysis of the unstable di- and tetra-hydroforms either an oxidation (mainly with iodine) or stabilization by reducing agents is applied. Due to the high polarity of pteridines, many analytical procedures employed ion-pair, ion-exchange or hydrophilic interaction liquid chromatography using mostly fluorescence detection. In the last decade, MS was found to be applicable. The objective of this Review is to show possibilities and different approaches in pteridine analysis in biological samples. (en)
Title	Determination of pteridines in biological samples with an emphasis on their stability Determination of pteridines in biological samples with an emphasis on their stability (en)
skos:prefLabel	Determination of pteridines in biological samples with an emphasis on their stability Determination of pteridines in biological samples with an emphasis on their stability (en)
skos:notation	RIV/00216208:11160/13:10146053!RIV14-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0235), S
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Solich, Petr Nováková, Lucie Tomšíková, Helena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	68918
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/13:10146053
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dihydropteridine reductase; marker pteridines; fluorescence detection; serum neopterin; human urine; fluorometric detection; L-ascorbic acid; GTP cyclohydrolase I; solid phase extraction; high performance liquid chromatography (en)
http://linked.open.../riv/klicoveSlovo	solid phase extraction GTP cyclohydrolase I dihydropteridine reductase fluorometric detection marker pteridines serum neopterin L-ascorbic acid high performance liquid chromatography human urine fluorescence detection
http://linked.open...odStatuVydavatele	PT - Portugalská republika
http://linked.open...ontrolniKodProRIV	[15BC4CB61B0D]
http://linked.open...i/riv/nazevZdroje	Bioanalysis
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Establishment of Research Team Focused on Experimental and Applied Biopharmacy
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Solich, Petr Tomšík, Pavel Nováková, Lucie Tomšíková, Helena
http://linked.open...ain/vavai/riv/wos	000325772200017
issn	1757-6180
number of pages	20 (xsd:int)
http://bibframe.org/vocab/doi	10.4155/bio.13.194
http://localhost/t...ganizacniJednotka	11160

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