About: Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics

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About: Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S1357272513002069
Description	Mammal multidrug and toxin extrusion protein 1 (MATE 1) encoded by SLC47A1 gene was described in 2005 as an efflux transporter that mediates proton-coupled organic cation secretion. In the kidney and liver, MATEs work in concert with organic cation transporters (OCTs), together representing an eliminatory pathway for organic cations. Over 40 clinically used drugs and several endogenous compounds are known substrates or inhibitors of MATEs. These transporters are supposed to modulate pharmacokinetics/toxicokinetics and to play a role in drug resistance and (patho)physiological processes. Drug drug interactions on MATE transporters and polymorphisms in SLC47A genes may affect renal excretion of substrate drugs. Expression and function of MATEs in tissues other than kidney and liver remain to be elucidated. Mammal multidrug and toxin extrusion protein 1 (MATE 1) encoded by SLC47A1 gene was described in 2005 as an efflux transporter that mediates proton-coupled organic cation secretion. In the kidney and liver, MATEs work in concert with organic cation transporters (OCTs), together representing an eliminatory pathway for organic cations. Over 40 clinically used drugs and several endogenous compounds are known substrates or inhibitors of MATEs. These transporters are supposed to modulate pharmacokinetics/toxicokinetics and to play a role in drug resistance and (patho)physiological processes. Drug drug interactions on MATE transporters and polymorphisms in SLC47A genes may affect renal excretion of substrate drugs. Expression and function of MATEs in tissues other than kidney and liver remain to be elucidated. (en)
Title	Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics (en)
skos:prefLabel	Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics Multidrug and toxin extrusion proteins (MATE/SLC47); role in pharmacokinetics (en)
skos:notation	RIV/00216208:11160/13:10145940!RIV14-GA0-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP303/12/0850)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Červený, Lukáš Štaud, František Novotná, Martina Ahmadimoghaddam, Davoud
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	90035
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/13:10145940
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Pharmacokinetics; Drug-drug interactions; Efflux transporter; Multidrug and toxin extrusion (en)
http://linked.open.../riv/klicoveSlovo	Efflux transporter Multidrug and toxin extrusion Drug-drug interactions Pharmacokinetics
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FC893C9D72DF]
http://linked.open...i/riv/nazevZdroje	International Journal of Biochemistry and Cell Biology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Transplacental pharmacokinetics of antiretroviral drugs; interactions with drug-efflux transporters
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Červený, Lukáš Čečková, Martina Štaud, František Ahmadimoghaddam, Davoud
http://linked.open...ain/vavai/riv/wos	000324605300006
issn	1357-2725
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.biocel.2013.06.022
http://localhost/t...ganizacniJednotka	11160

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