About: Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities

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About: Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Eleven alkaloids were isolated from fresh bulbs of Chlidanthus fragrans. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic experiments. All compounds were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro-P-nitroaniline was used as substrate. In biological assays, only the crinine type Amaryllidaceae alkaloid undulatine showed promising acetylcholinesterase and prolyl oligopeptidase inhibition activity. Other isolated compounds were considered inactive. Eleven alkaloids were isolated from fresh bulbs of Chlidanthus fragrans. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic experiments. All compounds were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro-P-nitroaniline was used as substrate. In biological assays, only the crinine type Amaryllidaceae alkaloid undulatine showed promising acetylcholinesterase and prolyl oligopeptidase inhibition activity. Other isolated compounds were considered inactive. (en)
Title	Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities (en)
skos:prefLabel	Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities (en)
skos:notation	RIV/00216208:11160/13:10145863!RIV14-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0235), P(GAP303/11/1907), S
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kulhánková, Andrea Cahlíková, Lucie Macáková, Kateřina Opletal, Lubomír Chlebek, Jakub Kuneš, Jiří Novák, Zdeněk Benešová, Nina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	60107
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/13:10145863
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prolyl oligopeptidase; butyrylcholinesterase; acetylcholinesterase; deoxypretazettine; Amaryllidaceae; Chlidanthus fragrans (en)
http://linked.open.../riv/klicoveSlovo	deoxypretazettine prolyl oligopeptidase Amaryllidaceae Chlidanthus fragrans acetylcholinesterase butyrylcholinesterase
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BA14D3B71354]
http://linked.open...i/riv/nazevZdroje	Natural product communications
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Establishment of Research Team Focused on Experimental and Applied Biopharmacy Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Hrabinová, Martina Kuča, Kamil Kuneš, Jiří Cahlíková, Lucie Chlebek, Jakub Jun, Daniel Kulhánková, Andrea Macáková, Kateřina Opletal, Lubomír Novák, Zdeněk Benešová, Nina
http://linked.open...ain/vavai/riv/wos	000326859300010
issn	1934-578X
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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