About: Development of novel stability-indicating method for the determination of dimetindene maleate and its impurities

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About: Development of novel stability-indicating method for the determination of dimetindene maleate and its impurities Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://link.springer.com/article/10.1007/s10337-013-2449-z/fulltext.html
Description	A novel and selective stability-indicating liquid chromatographic method has been developed and validated for the analysis of dimethindene maleate, the related substance 2-ethylpyridine, and three degradation products. Dimethindene maleate was subjected to forced degradation study by acid and basic hydrolysis, oxidation, and thermal decomposition. Three degradation products that were formed during the forced degradation study were separated from dimethindene using a Zorbax SB CN column (150 x 4.6 mm; 5 micro m); cyanopropyl-bonded stationary phase was applied for the first time for the separation of dimethindene and its impurities. A novel and selective stability-indicating liquid chromatographic method has been developed and validated for the analysis of dimethindene maleate, the related substance 2-ethylpyridine, and three degradation products. Dimethindene maleate was subjected to forced degradation study by acid and basic hydrolysis, oxidation, and thermal decomposition. Three degradation products that were formed during the forced degradation study were separated from dimethindene using a Zorbax SB CN column (150 x 4.6 mm; 5 micro m); cyanopropyl-bonded stationary phase was applied for the first time for the separation of dimethindene and its impurities. (en)
Title	Development of novel stability-indicating method for the determination of dimetindene maleate and its impurities Development of novel stability-indicating method for the determination of dimetindene maleate and its impurities (en)
skos:prefLabel	Development of novel stability-indicating method for the determination of dimetindene maleate and its impurities Development of novel stability-indicating method for the determination of dimetindene maleate and its impurities (en)
skos:notation	RIV/00216208:11160/13:10145623!RIV14-MSM-11160___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	21-22
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Solich, Petr Pannyová, Anna Havlíková, Lucie Matysová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	69165
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/13:10145623
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	forced degradation; impurities; dimethindene maleate; HPLC (en)
http://linked.open.../riv/klicoveSlovo	impurities dimethindene maleate forced degradation HPLC
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[5CF3A365B684]
http://linked.open...i/riv/nazevZdroje	Chromatographia
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Solich, Petr Havlíková, Lucie Matysová, Ludmila Pannyová, Anna
http://linked.open...ain/vavai/riv/wos	000326118900016
issn	0009-5893
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s10337-013-2449-z
http://localhost/t...ganizacniJednotka	11160

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