About: Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity

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About: Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/cbdv.201200144/pdf
Description	The bulbs of Zephyranthes robusta (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of 13 alkaloids. The chemical structures of the isolated compounds were elucidated by mass-spectrometric, and 1D- and 2D-NMR spectroscopic experiments. The complete NMR assignments were achieved for hippeastidine. All isolated alkaloids were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibitory activities using the Ellman's method. Significant acetylcholinesterase inhibition activity was exhibited by 8-O-demethylmaritidine (IC50(HuAChE) 28.0 +/- 0.9M). The bulbs of Zephyranthes robusta (Amaryllidaceae) have been extensively analyzed for their chemical constituents, resulting in the isolation of 13 alkaloids. The chemical structures of the isolated compounds were elucidated by mass-spectrometric, and 1D- and 2D-NMR spectroscopic experiments. The complete NMR assignments were achieved for hippeastidine. All isolated alkaloids were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibitory activities using the Ellman's method. Significant acetylcholinesterase inhibition activity was exhibited by 8-O-demethylmaritidine (IC50(HuAChE) 28.0 +/- 0.9M). (en)
Title	Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity (en)
skos:prefLabel	Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity (en)
skos:notation	RIV/00216208:11160/13:10144282!RIV14-MSM-11160___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kulhánková, Andrea Cahlíková, Lucie Macáková, Kateřina Opletal, Lubomír Kuneš, Jiří Novák, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	60108
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/13:10144282
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Inhibitors; Butyrylcholinesterase; Acetylcholinesterase; Hippeastidine; Alzheimer's disease; Zephyranthes robusta (en)
http://linked.open.../riv/klicoveSlovo	Hippeastidine Inhibitors Zephyranthes robusta Acetylcholinesterase Alzheimer's disease Butyrylcholinesterase
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[4747EAE05703]
http://linked.open...i/riv/nazevZdroje	Chemistry and Biodiversity
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Kuneš, Jiří Cahlíková, Lucie Kulhánková, Andrea Macáková, Kateřina Opletal, Lubomír Novák, Zdeněk
http://linked.open...ain/vavai/riv/wos	000320543600013
issn	1612-1872
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/cbdv.201200144
http://localhost/t...ganizacniJednotka	11160

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