About: A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK

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About: A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.eurekaselect.com/108094/article
Description	Tobacco smoking is the most widely known cause of human cancer-related death worldwide. NNK is one of the proved human carcinogens contributing to the development of several types of cancer. The carcinogenic effect of NNK depends on the metabolic pathway. Reduction of NNK by carbonyl reducing enzymes leads to the formation of NNAL. This pathway is generally regarded as detoxification pathway although the conditions and circumstances are quite complicated-the process depends on a formed enantiomer of NNAL. In this study a novel method for the determination of the metabolite NNAL was developed. This makes it possible to find and characterize carbonyl reducing enzymes that are involved in NNK metabolism. This simple HPLC method uses conventional HPLC instrumentation and is designed mainly for biochemical laboratories. A new microsomal carbonyl reducing enzyme participating in the metabolism of NNK in vitro has been described. Its activity was compared with other carbonyl reducing enzymes taking part in the biotransformation of NNK. Tobacco smoking is the most widely known cause of human cancer-related death worldwide. NNK is one of the proved human carcinogens contributing to the development of several types of cancer. The carcinogenic effect of NNK depends on the metabolic pathway. Reduction of NNK by carbonyl reducing enzymes leads to the formation of NNAL. This pathway is generally regarded as detoxification pathway although the conditions and circumstances are quite complicated-the process depends on a formed enantiomer of NNAL. In this study a novel method for the determination of the metabolite NNAL was developed. This makes it possible to find and characterize carbonyl reducing enzymes that are involved in NNK metabolism. This simple HPLC method uses conventional HPLC instrumentation and is designed mainly for biochemical laboratories. A new microsomal carbonyl reducing enzyme participating in the metabolism of NNK in vitro has been described. Its activity was compared with other carbonyl reducing enzymes taking part in the biotransformation of NNK. (en)
Title	A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK (en)
skos:prefLabel	A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK (en)
skos:notation	RIV/00216208:11160/12:10144110!RIV14-MSM-11160___
http://linked.open...avai/riv/aktivita	I S
http://linked.open...avai/riv/aktivity	I, S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Štambergová, Hana Wsól, Vladimír Škarydová, Lucie Zvěřinová, Michaela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	120606
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10144110
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	reducing; SDR; NNAL; NNK; HPLC-UV; enzymes; carbonyl; activity (en)
http://linked.open.../riv/klicoveSlovo	enzymes SDR NNAL NNK reducing activity carbonyl HPLC-UV
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[E3B54F37BCD7]
http://linked.open...i/riv/nazevZdroje	Drug Metabolism Letters
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Wsól, Vladimír Škarydová, Lucie Štambergová, Hana Zvěřinová, Michaela
issn	1872-3128
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/1872312811206030004
http://localhost/t...ganizacniJednotka	11160

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