About: Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride

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About: Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://wydawnictwo.umlub.pl/pharmacy/en/artykul/szczegoly/id/3579
Description	Nowadays research concerning new strategies for earlier diagnosis is among the most active areas in Alzheimer's science. Brain imaging techniques are among the most promising areas of research focused on early detection of Alzheimer's disease (AD). In the present study we describe radiolabeling of a novel acetylcholinesterase inhibitor 6-hydrazino-N-[5-(2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamino)pentyl]nicotinamide (5C-5) with 99m-Technetium (99mTc). Biodistribution study of compound 5C-5 radiolabeled with 99mTc after intravenous administration to rats was also performed. According to biodistribution study 99mTc-radioactivity was mainly localized in the liver, partly also in the kidney, lung and gastrointestinal tract. Furthermore, compound under study revealed comparatively rapid blood radioactivity clearance. Nowadays research concerning new strategies for earlier diagnosis is among the most active areas in Alzheimer's science. Brain imaging techniques are among the most promising areas of research focused on early detection of Alzheimer's disease (AD). In the present study we describe radiolabeling of a novel acetylcholinesterase inhibitor 6-hydrazino-N-[5-(2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamino)pentyl]nicotinamide (5C-5) with 99m-Technetium (99mTc). Biodistribution study of compound 5C-5 radiolabeled with 99mTc after intravenous administration to rats was also performed. According to biodistribution study 99mTc-radioactivity was mainly localized in the liver, partly also in the kidney, lung and gastrointestinal tract. Furthermore, compound under study revealed comparatively rapid blood radioactivity clearance. (en)
Title	Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride (en)
skos:prefLabel	Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride Radiolabeling and biodistribution of new acetylcholinesterase inhibitor - 6-Hydrazino-IV-[5-(2,3-dihydro-1H-cyclopenta[b] quinolin-9-ylamino)pentyl] nicotinamide hydrochloride (en)
skos:notation	RIV/00216208:11160/12:10133990!RIV13-MSM-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1738)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Lázníčková, Alice Lázníček, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	163957
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10133990
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	technetium; radiolabelling; potential PET marker (en)
http://linked.open.../riv/klicoveSlovo	potential PET marker technetium radiolabelling
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[7B656625651F]
http://linked.open...i/riv/nazevZdroje	Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Radiolabelled neuropeptides for cancer diagnosis and treatment
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Lázníček, Milan Lázníčková, Alice Markowicz, Magdalena Mikiciuk-Olasik, Elžbieta Szymański, Paweł
issn	0867-0609
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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