About: Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.woundsresearch.com/article/preclinical-evaluation-wound-treatment-hyaluronan-iodine-hydrogel
Description	A mixture of hyaluronan and iodine complex Kl(3) (Hyiodine (R)) has been developed to support wound healing. In this study, the effect of hyaluronan, Kl(3), and their combination on progression of wound healing in excision skin wounds in rats was determined. Methods. To evaluate the possible toxic effects of iodine after Hyiodine application for wound healing, iodine systemic absorption from the Hyiodine-treated wounds and its distribution profile were quantitatively described and compared after intravenous iodide administration using I-131 as a radiolabel. Results. Treatment of rats with Hyiodine resulted in an enhancement of wound healing, proved by greater degrees of wound contraction and reduction in mean wound healing time compared to other treated rats on hours 1, 2, 24, and 216. Even if wound therapy with Hyiodine resulted in systemic iodine uptake, the estimated iodine absorbed dose in human therapy is tolerable, and the theoretical risk of its systemic toxic effects is minimal. Conclusion. A hyaluronan-iodine hydrogel has a great potential for effective treatment of wounds. A mixture of hyaluronan and iodine complex Kl(3) (Hyiodine (R)) has been developed to support wound healing. In this study, the effect of hyaluronan, Kl(3), and their combination on progression of wound healing in excision skin wounds in rats was determined. Methods. To evaluate the possible toxic effects of iodine after Hyiodine application for wound healing, iodine systemic absorption from the Hyiodine-treated wounds and its distribution profile were quantitatively described and compared after intravenous iodide administration using I-131 as a radiolabel. Results. Treatment of rats with Hyiodine resulted in an enhancement of wound healing, proved by greater degrees of wound contraction and reduction in mean wound healing time compared to other treated rats on hours 1, 2, 24, and 216. Even if wound therapy with Hyiodine resulted in systemic iodine uptake, the estimated iodine absorbed dose in human therapy is tolerable, and the theoretical risk of its systemic toxic effects is minimal. Conclusion. A hyaluronan-iodine hydrogel has a great potential for effective treatment of wounds. (en)
Title	Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel (en)
skos:prefLabel	Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel Preclinical Evaluation of Wound Treatment with Hyaluronan-Iodine Hydrogel (en)
skos:notation	RIV/00216208:11160/12:10124671!RIV13-MSM-11160___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Lázníčková, Alice Lázníček, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	160957
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10124671
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	therapy; products; repair; toxicity; tissue-injury; full-thickness wounds (en)
http://linked.open.../riv/klicoveSlovo	therapy toxicity repair products full-thickness wounds tissue-injury
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[046F874D0702]
http://linked.open...i/riv/nazevZdroje	Wounds
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Velebný, Vladimír Švík, Karol Lázníček, Milan Lázníčková, Alice
http://linked.open...ain/vavai/riv/wos	000308778300006
issn	1044-7946
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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