About: Chromatographic determination of active compounds in topical formulations

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pubs.rsc.org/en/content/articlepdf/2011/ay/c1ay05336a
Description	The aim of this study was to develop and validate new methods for the determination of active compounds in topical gels. The method for the determination of nonoxinol-9 and trimecaine hydrochloride in lubricant gel by HPLC with UV detection was described. Separation was carried out using a Discovery ZR-PBD analytical column (150 x 4.6 mm, 5 mu m), and a mobile phase composed of a mixture of triethylammonium acetate buffer (pH 9; 50 mM) and methanol (22 : 78, v/v). Determination of terpinen-4-ol in lubricant gel was achieved by GC with a flame ionization detector (FID). An Alltech-AT-624 (0.32 mm ID x 30 m, 1.8 mu m film thickness) fused-silica capillary column and helium as the carrier gas, at a flow rate of 28 cm s(-1), were employed. The analysis time was less than 7.5 min for HPLC and 5 min for GC analyses. Both methods were successfully applied to the analysis of pharmaceuticals. The aim of this study was to develop and validate new methods for the determination of active compounds in topical gels. The method for the determination of nonoxinol-9 and trimecaine hydrochloride in lubricant gel by HPLC with UV detection was described. Separation was carried out using a Discovery ZR-PBD analytical column (150 x 4.6 mm, 5 mu m), and a mobile phase composed of a mixture of triethylammonium acetate buffer (pH 9; 50 mM) and methanol (22 : 78, v/v). Determination of terpinen-4-ol in lubricant gel was achieved by GC with a flame ionization detector (FID). An Alltech-AT-624 (0.32 mm ID x 30 m, 1.8 mu m film thickness) fused-silica capillary column and helium as the carrier gas, at a flow rate of 28 cm s(-1), were employed. The analysis time was less than 7.5 min for HPLC and 5 min for GC analyses. Both methods were successfully applied to the analysis of pharmaceuticals. (en)
Title	Chromatographic determination of active compounds in topical formulations Chromatographic determination of active compounds in topical formulations (en)
skos:prefLabel	Chromatographic determination of active compounds in topical formulations Chromatographic determination of active compounds in topical formulations (en)
skos:notation	RIV/00216208:11160/12:10124373!RIV13-MSM-11160___
http://linked.open...avai/riv/aktivita	I S Z
http://linked.open...avai/riv/aktivity	I, S, Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Sklenářová, Hana Solich, Petr Koblová, Petra Galla, Lubomír Havlíková, Lucie Matysová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	127123
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10124373
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	assay; spermicide nonoxynol-9; performance liquid-chromatography; tea tree oil (en)
http://linked.open.../riv/klicoveSlovo	performance liquid-chromatography assay spermicide nonoxynol-9 tea tree oil
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B8243EE37A25]
http://linked.open...i/riv/nazevZdroje	Analytical Methods
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Sklenářová, Hana Solich, Petr Koblová, Petra Galla, Lubomír Havlíková, Lucie Matysová, Ludmila
http://linked.open...ain/vavai/riv/wos	000304768600010
http://linked.open...n/vavai/riv/zamer	Research of new drug structures
issn	1759-9660
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c1ay05336a
http://localhost/t...ganizacniJednotka	11160

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