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Description
  • Eighteen salicylanilide benzoates were evaluated for their inhibition potential against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii; minimum inhibitory concentration values ranged from 0.5 to 16 mu mol/L. The most active esters underwent additional biological assays. Four benzoates inhibited effectively the growth of five multidrug-resistant strains and one extensively drug-resistant strain of M. tuberculosis at low concentrations (0.25-2 mu mol/L) regardless of the resistance patterns. The highest rate of multidrug-resistant mycobacteria inhibition expressed 4-chloro-2-[4-(trifluoromethyl)-phenylcarbamoyl]phenyl benzoate (0.25-1 mu mol/L).
  • Eighteen salicylanilide benzoates were evaluated for their inhibition potential against Mycobacterium tuberculosis, Mycobacterium avium and two strains of Mycobacterium kansasii; minimum inhibitory concentration values ranged from 0.5 to 16 mu mol/L. The most active esters underwent additional biological assays. Four benzoates inhibited effectively the growth of five multidrug-resistant strains and one extensively drug-resistant strain of M. tuberculosis at low concentrations (0.25-2 mu mol/L) regardless of the resistance patterns. The highest rate of multidrug-resistant mycobacteria inhibition expressed 4-chloro-2-[4-(trifluoromethyl)-phenylcarbamoyl]phenyl benzoate (0.25-1 mu mol/L). (en)
Title
  • Antimycobacterial Assessment of Salicylanilide Benzoates including Multidrug-Resistant Tuberculosis Strains
  • Antimycobacterial Assessment of Salicylanilide Benzoates including Multidrug-Resistant Tuberculosis Strains (en)
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  • Antimycobacterial Assessment of Salicylanilide Benzoates including Multidrug-Resistant Tuberculosis Strains
  • Antimycobacterial Assessment of Salicylanilide Benzoates including Multidrug-Resistant Tuberculosis Strains (en)
skos:notation
  • RIV/00216208:11160/12:10124276!RIV13-MZ0-11160___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(NT13346), S
http://linked.open...iv/cisloPeriodika
  • 11
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  • 122980
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  • RIV/00216208:11160/12:10124276
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  • salicylanilide ester; salicylanilide; multidrug-resistant tuberculosis; in vitro activity; cytotoxicity; benzoic acid ester; antimycobacterial activity (en)
http://linked.open.../riv/klicoveSlovo
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  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [EE28ACA3F92A]
http://linked.open...i/riv/nazevZdroje
  • Molecules
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  • 17
http://linked.open...iv/tvurceVysledku
  • Krátký, Martin
  • Vinšová, Jarmila
  • Stolaříková, Jiřina
http://linked.open...ain/vavai/riv/wos
  • 000311428400026
issn
  • 1420-3049
number of pages
http://bibframe.org/vocab/doi
  • 10.3390/molecules171112812
http://localhost/t...ganizacniJednotka
  • 11160
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