About: In vitro platelet antiaggregatory properties of 4-methylcoumarins

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0300908412003641
Description	The aim of this study was to analyse a series of simple 4-methylcoumarins for their antiplatelet activity. Human plasma platelet suspensions were treated with different aggregation inducers [arachidonic acid (AA), collagen and ADP] in the presence of the 4-methylcoumarins. Complementary experiments were performed to explain the mechanism of action. 5,7-Dihydroxy-4-methylcoumarins, in particular those containing a lipophilic side chain at C-3, reached the activity of acetylsalicylic acid on AA-induced aggregation. Other tested coumarins were less active. Some of the tested compounds mildly inhibited either collagen- or ADP-induced aggregation. 5,7- Dihydroxy-4-methylcoumarins did not interfere with the function of thromboxane synthase, but were competitive antagonists of thromboxane A2 receptors and inhibited cyclooxygenase-1 as well. 5,7-Dihydroxy-4-methylcoumarins appear to be promising candidates for the extension of the current spectrum of antiplatelet drugs. The aim of this study was to analyse a series of simple 4-methylcoumarins for their antiplatelet activity. Human plasma platelet suspensions were treated with different aggregation inducers [arachidonic acid (AA), collagen and ADP] in the presence of the 4-methylcoumarins. Complementary experiments were performed to explain the mechanism of action. 5,7-Dihydroxy-4-methylcoumarins, in particular those containing a lipophilic side chain at C-3, reached the activity of acetylsalicylic acid on AA-induced aggregation. Other tested coumarins were less active. Some of the tested compounds mildly inhibited either collagen- or ADP-induced aggregation. 5,7- Dihydroxy-4-methylcoumarins did not interfere with the function of thromboxane synthase, but were competitive antagonists of thromboxane A2 receptors and inhibited cyclooxygenase-1 as well. 5,7-Dihydroxy-4-methylcoumarins appear to be promising candidates for the extension of the current spectrum of antiplatelet drugs. (en)
Title	In vitro platelet antiaggregatory properties of 4-methylcoumarins In vitro platelet antiaggregatory properties of 4-methylcoumarins (en)
skos:prefLabel	In vitro platelet antiaggregatory properties of 4-methylcoumarins In vitro platelet antiaggregatory properties of 4-methylcoumarins (en)
skos:notation	RIV/00216208:11160/12:10124197!RIV13-MSM-11160___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GBP303/12/G163), S
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Macáková, Kateřina Pávek, Petr Jahodář, Luděk Filipský, Tomáš Mladěnka, Přemysl Hrdina, Radomír Karlíčková, Jana Řeháková, Zuzana Říha, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	141046
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/12:10124197
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Arachidonic acid; Acetylsalicylic acid; Antiaggregatory; Platelet; Coumarins (en)
http://linked.open.../riv/klicoveSlovo	Acetylsalicylic acid Antiaggregatory Arachidonic acid Coumarins Platelet
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[8C4DF4DFE4E5]
http://linked.open...i/riv/nazevZdroje	Biochimie
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of drug-dietary supplements interactions and nutrigenetics
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	94
http://linked.open...iv/tvurceVysledku	Pávek, Petr Macáková, Kateřina Filipský, Tomáš Hrdina, Radomír Jahodář, Luděk Mladěnka, Přemysl Saso, Luciano Karlíčková, Jana Parmar, Virinder S Prasad, Ashok K Řeháková, Zuzana Říha, Michal
http://linked.open...ain/vavai/riv/wos	000312517800026
issn	0300-9084
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.biochi.2012.09.006
http://localhost/t...ganizacniJednotka	11160

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