About: Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model

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About: Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.prolekare.cz/ceska-slovenska-farmacie-clanek?id=34296
Description	99mTc-MAG3 and 99mTc-DMSA are renal radiodiagnostics in clinical use. However, the renal mechanisms determining their transport within the kidney are not fully explained. The investigation compared renal uptake of the studied compounds and evaluated contribution of active and passive transport mechanisms to the renal accumulation. As the experimental model, freshly isolated rat renal cells were used. The results documented significant quantitative and qualitative differences between the tested agents. The found data indicated that 99mTc-DMSA was transported across the membranes of the renal cells almost exclusively by passive transport. On the other side, 99mTc-MAG3 accumulation rate in the rat renal cells was several times higher and was mediated by active transport mechanisms. 99mTc-MAG3 and 99mTc-DMSA are renal radiodiagnostics in clinical use. However, the renal mechanisms determining their transport within the kidney are not fully explained. The investigation compared renal uptake of the studied compounds and evaluated contribution of active and passive transport mechanisms to the renal accumulation. As the experimental model, freshly isolated rat renal cells were used. The results documented significant quantitative and qualitative differences between the tested agents. The found data indicated that 99mTc-DMSA was transported across the membranes of the renal cells almost exclusively by passive transport. On the other side, 99mTc-MAG3 accumulation rate in the rat renal cells was several times higher and was mediated by active transport mechanisms. (en)
Title	Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model (en)
skos:prefLabel	Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model Study on 99mTc-MAG3 and 99mTc-DMSA renal accumulation using in vitro cellular model (en)
skos:notation	RIV/00216208:11160/11:10100471!RIV12-MSM-11160___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mandíková, Jana Trejtnar, František Nový, Zbyněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	233178
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/11:10100471
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bioelimination; membrane transport; renal radiodiagnostics (en)
http://linked.open.../riv/klicoveSlovo	bioelimination membrane transport renal radiodiagnostics
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[2C0F969AD132]
http://linked.open...i/riv/nazevZdroje	Česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	60
http://linked.open...iv/tvurceVysledku	Mandíková, Jana Trejtnar, František Nový, Zbyněk
issn	1210-7816
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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