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  • Design, results of in vitro antimycobacterial evaluation, and study of structure-activity relationships of various pyrazinecarboxylic acid reversible derivatives are presented. This review deals with some pyrazinamide analogues/prodrugs derived from N-phenylpyrazine-2-carboxamides (1), arylaminopyrazine-2,5-dicarbonitriles (2), aryl/alkylsulphanylpyrazines (3,4), and aroylpyrazines (5) effecting >50% inhibition in the primary antimycobacterial screen. The promising pyrazine candidates for further antimycobacterial evaluation were discovered. Results give good view onto structure-activity relationships of these analogues and promise even better activity of new compounds prepared after some structure optimization experiments.
  • Design, results of in vitro antimycobacterial evaluation, and study of structure-activity relationships of various pyrazinecarboxylic acid reversible derivatives are presented. This review deals with some pyrazinamide analogues/prodrugs derived from N-phenylpyrazine-2-carboxamides (1), arylaminopyrazine-2,5-dicarbonitriles (2), aryl/alkylsulphanylpyrazines (3,4), and aroylpyrazines (5) effecting >50% inhibition in the primary antimycobacterial screen. The promising pyrazine candidates for further antimycobacterial evaluation were discovered. Results give good view onto structure-activity relationships of these analogues and promise even better activity of new compounds prepared after some structure optimization experiments. (en)
Title
  • Antimycobacterial evaluation of pyrazinoic acid reversible derivatives
  • Antimycobacterial evaluation of pyrazinoic acid reversible derivatives (en)
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  • Antimycobacterial evaluation of pyrazinoic acid reversible derivatives
  • Antimycobacterial evaluation of pyrazinoic acid reversible derivatives (en)
skos:notation
  • RIV/00216208:11160/11:10100341!RIV12-MZ0-11160___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NS10367), Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika
  • 32
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  • 186479
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11160/11:10100341
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  • structure-activity relationships; in vitro antimycobacterial evaluation; pyrazines (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [F2C7713E4406]
http://linked.open...i/riv/nazevZdroje
  • Current Pharmaceutical Design
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 17
http://linked.open...iv/tvurceVysledku
  • Doležal, Martin
  • Kešetovičová, Diana
  • Zitko, Jan
http://linked.open...ain/vavai/riv/wos
  • 000299637000004
http://linked.open...n/vavai/riv/zamer
issn
  • 1381-6128
number of pages
http://localhost/t...ganizacniJednotka
  • 11160
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