About: In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain

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About: In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://node.nel.edu/?node_id=11512
Description	Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents). Effects both of AChE inhibitors (tacrine, 7-methoxytacrine) and oximes (pralidoxime, trimedoxime, obidoxime, methoxime, HI-6) on Complex I of electron transport chain (ETC) were examined. The enzyme activity was measured spectrophotometrically in crude mitochondrial fraction isolated from pig brain. Our results showed statistically significant Complex I inhibition by tacrine, other drugs did not affect the enzyme activity significantly. Various types of oximes reactivate AChE and are commonly used as antidotes against organophosphates (pesticides, nerve agents). Effects both of AChE inhibitors (tacrine, 7-methoxytacrine) and oximes (pralidoxime, trimedoxime, obidoxime, methoxime, HI-6) on Complex I of electron transport chain (ETC) were examined. The enzyme activity was measured spectrophotometrically in crude mitochondrial fraction isolated from pig brain. Our results showed statistically significant Complex I inhibition by tacrine, other drugs did not affect the enzyme activity significantly. (en)
Title	In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain (en)
skos:prefLabel	In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain (en)
skos:notation	RIV/00216208:11160/11:10100203!RIV12-MSM-11160___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GAP303/11/1907), S, Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Korábečný, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	204036
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/11:10100203
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tacrine; oxime; NADH dehydrogenase; 7-MEOTA; electron transport chain; acetylcholinesterase (en)
http://linked.open.../riv/klicoveSlovo	7-MEOTA NADH dehydrogenase electron transport chain tacrine acetylcholinesterase oxime
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[37EA00EF6225]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Fišar, Zdeněk Hroudová, Jana Kuča, Kamil Korábečný, Jan
http://linked.open...ain/vavai/riv/wos	000294089700008
http://linked.open...n/vavai/riv/zamer	Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	0172-780X
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	11160

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