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Description
| - The paper deals with the concept of simple automated creation of gradient profile of the mobile phase for gradient-elution sequential injection chromatography (GE-SIC). The feasibility and merits of this concept are demonstrated on the separation and simultaneous assay of indomethacin as active principle and of its two degradation products (5-methoxy-2-methylindoleacetic acid and 4-chloro-benzoic acid) in a topical pharmaceutical formulation. The GE-SIC separation was performed with a FIAlab (R) 3000 SIC set-up (USA) equipped with an Onyx (TM) Monolithic C18 (25 mm x 4.6 mm, Phenomenex (R)) column, a six-port selection valve, a 5-mL syringe pump and a fiber-optics UV CCD detector. Ketoprofen was used as an internal standard (IS). The gradient elution was achieved by automated reproducible mixing of acetonitrile and aqueous 0.2% phosphoric acid in the holding coil of the SIC system.
- The paper deals with the concept of simple automated creation of gradient profile of the mobile phase for gradient-elution sequential injection chromatography (GE-SIC). The feasibility and merits of this concept are demonstrated on the separation and simultaneous assay of indomethacin as active principle and of its two degradation products (5-methoxy-2-methylindoleacetic acid and 4-chloro-benzoic acid) in a topical pharmaceutical formulation. The GE-SIC separation was performed with a FIAlab (R) 3000 SIC set-up (USA) equipped with an Onyx (TM) Monolithic C18 (25 mm x 4.6 mm, Phenomenex (R)) column, a six-port selection valve, a 5-mL syringe pump and a fiber-optics UV CCD detector. Ketoprofen was used as an internal standard (IS). The gradient elution was achieved by automated reproducible mixing of acetonitrile and aqueous 0.2% phosphoric acid in the holding coil of the SIC system. (en)
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Title
| - Simple automated generation of gradient elution conditions in sequential injection chromatography using monolithic column
- Simple automated generation of gradient elution conditions in sequential injection chromatography using monolithic column (en)
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skos:prefLabel
| - Simple automated generation of gradient elution conditions in sequential injection chromatography using monolithic column
- Simple automated generation of gradient elution conditions in sequential injection chromatography using monolithic column (en)
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skos:notation
| - RIV/00216208:11160/11:10100196!RIV12-MSM-11160___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11160/11:10100196
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - sequential injection chromatography; monolithic column; indomethacin; HPLC; gradient elution; degradation products (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Sklenářová, Hana
- Solich, Petr
- Polášek, Miroslav
- Chocholouš, Petr
- Koblová, Petra
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.talanta.2011.01.029
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http://localhost/t...ganizacniJednotka
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