About: Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats

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About: Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0024320511004243
Description	The aim of the study was to evaluate iron biochemistry and contributing liver mechanisms during obstructive cholestasis and pravastatin treatment in rats. A rat model of cholestasis induced by bile duct ligation (BDL) was used for the study. The administration of pravastatin to BDL animals attenuated proliferation changes in liver parenchyma, prevented HO-1 induction, restored hepatic mRNA hepcidin expression to control levels and induced the mRNA expression of ferritin, transferrin receptors (TfR1/2) and divalent metal transporter-1. This was accompanied by an increased content of intrahepatic iron when compared to the BDL animals, and a reduction of hyperbilirubinemia. In conclusion, cholestasis-induced increase in plasma and decrease in hepatic iron levels were associated with up-regulation of liver HO-1 and ferroportin 1. Pravastatin alleviated cholestatic liver impairment and raised liver iron content by modulation of heme catabolism and an increase of hepatic iron uptake and storage capacity. The aim of the study was to evaluate iron biochemistry and contributing liver mechanisms during obstructive cholestasis and pravastatin treatment in rats. A rat model of cholestasis induced by bile duct ligation (BDL) was used for the study. The administration of pravastatin to BDL animals attenuated proliferation changes in liver parenchyma, prevented HO-1 induction, restored hepatic mRNA hepcidin expression to control levels and induced the mRNA expression of ferritin, transferrin receptors (TfR1/2) and divalent metal transporter-1. This was accompanied by an increased content of intrahepatic iron when compared to the BDL animals, and a reduction of hyperbilirubinemia. In conclusion, cholestasis-induced increase in plasma and decrease in hepatic iron levels were associated with up-regulation of liver HO-1 and ferroportin 1. Pravastatin alleviated cholestatic liver impairment and raised liver iron content by modulation of heme catabolism and an increase of hepatic iron uptake and storage capacity. (en)
Title	Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats (en)
skos:prefLabel	Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats (en)
skos:notation	RIV/00216208:11160/11:10099490!RIV12-MSM-11160___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	19-20
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Brčáková, Eva Nachtigal, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	213322
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/11:10099490
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ferroportin 1; hepcidin; iron; cholestasis; pravastatin (en)
http://linked.open.../riv/klicoveSlovo	cholestasis ferroportin 1 pravastatin hepcidin iron
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[20872B7EBAAF]
http://linked.open...i/riv/nazevZdroje	Life Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	89
http://linked.open...iv/tvurceVysledku	Brčáková, Eva Mičuda, Stanislav Mokrý, Jaroslav Nachtigal, Petr Kolouchová, Gabriela Cermanová, Jolana Fuksa, Leoš Hiršová, Petra Laštůvková, Hana
http://linked.open...ain/vavai/riv/wos	000296311800007
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0024-3205
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.lfs.2011.08.014
http://localhost/t...ganizacniJednotka	11160

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